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NCT04781478
Treatment of Periodontal Disease With Two Different Bioactive Gels for Home Oral Care
NA trial testing Application of Biorepair Gel in Periodontal Diseases in 30 participants. Completed in 15 October 2021.
10 October 2021
Quick facts
| Lead sponsor | University of Pavia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 16 March 2021 |
| Primary completion | 10 October 2021 |
| Estimated completion | 15 October 2021 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Application of Biorepair Gel
- Irrigation of Chlorhexidine 1.00% gel
Conditions studied
- Periodontal Diseases — all drugs for Periodontal Diseases →
Sponsor
University of Pavia
Who can join
Adults 18 to 70, any sex, with Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is an open-label split-mouth study in which periodontal patients will be treated in order to obtain periodontal health. After non-surgical therapy and air-perio polishing, a periodontal in-situ gelling product (Biorepair Implant Bioactive gel) will be applied in periodontal pockets in two quadrants (Q1-Q3 or Q2-Q4) of the mouth of the participants. At the same time, pockets of the contralateral quadrant will be irrigated with chlorhexidine gel 1%. Patients will continue to use gels at home for the following 14 days and on the same quadrants. Professional ora hygiene session will be performed after 1, 3 and 6 months from the baseline. Patients are divided into two groups with inverted quadrants administration in order to evaluate the improvements of periodontal inflammation indices and to assess the efficacy of Biorepair Implant Bioactive gel compared to chlorhexidine 1% gel treatment.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial.
Butera A, Gallo S, Pascadopoli M, Taccardi D, et al · · 2022 · cited 71× · PMID 35052995 · DOI 10.3390/antibiotics11010118
Verify or expand the search:
- PubMed search for NCT04781478
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other University of Pavia trials
Trials by the same sponsor.
- NCT07491536 — Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis · NA · recruiting
- NCT07421128 — The Pause, Learn, and Activate Yourself (PLAY) · NA · not yet recruiting
- NCT07199712 — Ozone Therapy for Oral Mucositis in Patients Receiving Head and Neck Cancer Radio- and Chemotherapy · NA · completed
- NCT07088653 — Comparison of 0.12% Chlorhexidine and MicroRepair ABX Mouthwash in Gingivitis Management · NA · completed
- NCT07140146 — Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04781478 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pavia
- Last refreshed: 8 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04781478.
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