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NCT04779047

Comparative Therapeutic Efficacy and Safety of Different Antiviral and Anti Inflammatory Drugs in COVID-19 Patients.

Status unknown Phase 4 Last updated 17 March 2021
What this trial tests

Phase 4 trial testing Remdesivir in Covid19 in 150 participants. Status unknown.

Timeline
1 October 2020
Primary endpoint
10 March 2021
5 April 2021

Quick facts

Lead sponsorOctober 6 University
PhasePhase 4
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment150
Start date1 October 2020
Primary completion10 March 2021
Estimated completion5 April 2021
Sites1 location across Egypt

Drugs / interventions tested

Conditions studied

Sponsor

October 6 University

Who can join

Adults 18 to 88, any sex, with Covid19 or Pneumonia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Comparison outcomes of a large cohort of moderate and severe COVID-19 patients received different Antiviral and Anti Inflammatory Drugs.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment.
    Drożdżal S, Rosik J, Lechowicz K, Machaj F, et al · · 2021 · cited 186× · PMID 34991982 · DOI 10.1016/j.drup.2021.100794
  2. Immunotherapy of COVID-19: Inside and Beyond IL-6 Signalling.
    Zizzo G, Tamburello A, Castelnovo L, Laria A, et al · · 2022 · cited 55× · PMID 35340805 · DOI 10.3389/fimmu.2022.795315
  3. Inflammatory pathways in COVID-19: Mechanism and therapeutic interventions.
    Jiang Y, Zhao T, Zhou X, Xiang Y, et al · · 2022 · cited 44× · PMID 35923762 · DOI 10.1002/mco2.154
  4. Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells.
    Hafezi B, Chan L, Knapp JP, Karimi N, et al · · 2021 · cited 41× · PMID 34359931 · DOI 10.3390/cells10071761
  5. An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19).
    Elahi R, Karami P, Heidary AH, Esmaeilzadeh A. · · 2022 · cited 33× · PMID 35074571 · DOI 10.1016/j.intimp.2022.108536
  6. Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients.
    Sarhan RM, Harb HS, Abou Warda AE, Salem-Bekhit MM, et al · · 2022 · cited 27× · PMID 34764044 · DOI 10.1016/j.jiph.2021.10.024
  7. The Role of Cyclodextrins in COVID-19 Therapy-A Literature Review.
    Almeida B, Domingues C, Mascarenhas-Melo F, Silva I, et al · · 2023 · cited 17× · PMID 36769299 · DOI 10.3390/ijms24032974
  8. Mast cells: Therapeutic targets for COVID-19 and beyond.
    Lam HY, Tergaonkar V, Kumar AP, Ahn KS. · · 2021 · cited 17× · PMID 34467628 · DOI 10.1002/iub.2552

Verify or expand the search:

Other trials of Remdesivir

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Other October 6 University trials

Trials by the same sponsor.

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