Who is sponsoring NCT04778267?

NCT04778267 is sponsored by Kasr El Aini Hospital.

What drugs are being tested in NCT04778267?

Interventions in NCT04778267: Bupivacaine Hydrochloride, Dexamethasone phosphate.

What condition does NCT04778267 study?

NCT04778267 studies Modified Radical Mastectomy.

Is NCT04778267 still recruiting?

NCT04778267 is currently completed. Last updated 13 March 2023.

Last reviewed 2023-03-13 · How we verify

NCT04778267

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of Combined Erector Spinae and Pecto-intercostal Fascial Plane Blocks Versus Thoracic Paravertebral Block in Perioperative Pain in Modified Radical Mastectomy

Completed Phase 4 Last updated 13 March 2023

What this trial tests

Phase 4 trial testing Bupivacaine Hydrochloride in Modified Radical Mastectomy in 30 participants. Completed in 10 March 2023.

Timeline

12 March 2021

Primary endpoint
9 March 2023

10 March 2023

Quick facts

Lead sponsor	Kasr El Aini Hospital
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	30
Start date	12 March 2021
Primary completion	9 March 2023
Estimated completion	10 March 2023
Sites	1 location across Egypt

Drugs / interventions tested

Bupivacaine Hydrochloride (Bupivacaine Hydrochloride) — full drug profile →
Dexamethasone phosphate

Conditions studied

Modified Radical Mastectomy — all drugs for Modified Radical Mastectomy →

Sponsor

Kasr El Aini Hospital

Who can join

Adults 18 to 60, female only, with Modified Radical Mastectomy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Erector spinae plane block (ESPB) is a new evolving fascial pain block in the era of regional anaesthesia. ESPB was applied in varieties of surgeries and provided an eminent role in trauma patient especially those with fracture ribs. ESPB exhibits simple, safe and easy technique with minimal or no sympathetic blockade effects, thus gaining popularity in wide range of surgeries. The optimum effective dose of local anaesthetic, the effective volume of drug used for desired dermatomes. Comparison with different regional blocks is preferable to know the optimum analgesic technique for those population of patients (4). Many studies have already compared solo ESPB with thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), serratus anterior plane block (SAPB) and pectoral nerves block. Only few case reports described the combination effect of rhomboid intercostal, transversus thoracic muscle and parasternal plane blocks to ESPB in modified radical mastectomy.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Bupivacaine Hydrochloride

Trials testing the same drug.

NCT07512635 — Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Quality of Recovery in VATS Partial Pneumonectomy · Phase 4 · not yet recruiting
NCT06704698 — Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery · NA · recruiting
NCT06575699 — Rectus Sheath Block for Analgesia After Gynecological Laparotomy · Phase 4 · completed
NCT06577233 — Superior Hypogastric Nerve Plexus Block With Bupivacaine After Robotic Resection of Endometriosis · Phase 4 · recruiting
NCT06569953 — Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chron · Phase 4 · recruiting

Other recruiting trials for Modified Radical Mastectomy

Currently open trials in the same condition.

NCT07367568 — Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy · NA · recruiting
NCT06947330 — Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Rad · Phase 3 · recruiting
NCT06815887 — Adding Magnesium Sulfate to Local Anesthetic in Combined Pectoral Nerve and Stellate Ganglion Block for Postoperative Pa · NA · recruiting

Other Kasr El Aini Hospital trials

Trials by the same sponsor.

NCT07438652 — Effect of Mediterranean vs Paleolithic Diet on RA Activity, Sarcopenia and QOL: 12-Week RCT · NA · recruiting
NCT07488039 — Labroplasty in Cases of Anterior Shoulder Instability With Subcritical Glenoid Bone Loss · NA · recruiting
NCT07274280 — Comparative Evaluation of Ambu AuraGain, LarySeal Pro and I-gel in Pediatric Airway Management for Day-Case Surgery Unde · NA · not yet recruiting
NCT07348146 — Hand-Sewn vs. Stapled Anastomosis in SADI-S: Early Postoperative Complications. · NA · enrolling by invitation
NCT07077265 — Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in Elderly · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04778267 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kasr El Aini Hospital
Last refreshed: 13 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04778267.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing