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NCT07512635
Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Quality of Recovery in VATS Partial Pneumonectomy
Phase 4 trial testing Bupivacaine Hydrochloride in Pulmonary Nodule in 96 participants. Not yet recruiting.
7 April 2026
Quick facts
| Lead sponsor | Sanming First Hospital |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 96 |
| Start date | 6 April 2026 |
| Primary completion | 7 April 2026 |
| Estimated completion | 30 April 2027 |
Drugs / interventions tested
- Bupivacaine Hydrochloride (Bupivacaine Hydrochloride) — full drug profile →
- Bupivacaine liposome
Conditions studied
- Pulmonary Nodule — all drugs for Pulmonary Nodule →
- Liposomal Bupivacaine — all drugs for Liposomal Bupivacaine →
Sponsor
Sanming First Hospital
Who can join
Adults 18 to 65, any sex, with Pulmonary Nodule or Liposomal Bupivacaine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive approach for partial pneumonectomy, but postoperative pain remains a major challenge affecting recovery. Intercostal nerve block (ICNB) with conventional local anesthetics provides limited duration of analgesia, often insufficient to cover the peak pain period after surgery. Liposomal bupivacaine is a long-acting formulation designed to provide extended analgesia up to 72 hours. This study aims to evaluate the effect of preoperative ICNB with liposomal bupivacaine compared with conventional bupivacaine hydrochloride on postoperative quality of recovery in patients undergoing VATS partial pneumonectomy. The primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours postoperatively. We hypothesize that liposomal bupivacaine ICNB results in superior recovery quality compared with conventional bupivacaine, with reduced postoperative pain and opioid consumption.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07512635
- Europe PMC full search
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Related trials
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Trials testing the same drug.
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- NCT06569953 — Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chron · Phase 4 · recruiting
- NCT06386770 — Systemic Versus Local Dexmedetomidine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block · Phase 3 · recruiting
Other recruiting trials for Pulmonary Nodule
Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07512635 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sanming First Hospital
- Last refreshed: 13 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07512635.
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