NCT04767347 (Aim1) is a NA clinical trial of 23.0°C WBGT - Fixed Work Rate in Hot Weather; Adverse Effect, sponsored by Indiana University.

Who is sponsoring NCT04767347?

NCT04767347 is sponsored by Indiana University.

What drugs are being tested in NCT04767347?

Interventions in NCT04767347: 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate, 28.5°C WBGT - Fixed Work Rate, 35.5°C WBGT - Fixed Work Rate, 26.0°C WBGT - Fixed work-to-rest ratio, 30.5°C WBGT - Fixed work-to-rest ratio, 30.5°C WBGT - Fixed work-to-rest ratio (high intensity).

What condition does NCT04767347 study?

NCT04767347 studies Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia, Dehydration.

Is NCT04767347 still recruiting?

NCT04767347 is currently completed. Last updated 8 November 2023.

Last reviewed 2023-11-08 · How we verify

NCT04767347: Aim1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Renal Considerations in the Heat Stress Recommendations

Completed NA Last updated 8 November 2023

What this trial tests

NA trial testing 23.0°C WBGT - Fixed Work Rate in Hot Weather; Adverse Effect in 38 participants. Completed in 4 May 2023.

Timeline

1 March 2021

Primary endpoint
4 May 2023

4 May 2023

Quick facts

Lead sponsor	Indiana University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	38
Start date	1 March 2021
Primary completion	4 May 2023
Estimated completion	4 May 2023
Sites	1 location across United States

Drugs / interventions tested

23.0°C WBGT - Fixed Work Rate
25.5°C WBGT - Fixed Work Rate
27.5°C WBGT - Fixed Work Rate
28.5°C WBGT - Fixed Work Rate
35.5°C WBGT - Fixed Work Rate
26.0°C WBGT - Fixed work-to-rest ratio
30.5°C WBGT - Fixed work-to-rest ratio
30.5°C WBGT - Fixed work-to-rest ratio (high intensity)

Conditions studied

Hot Weather; Adverse Effect — all drugs for Hot Weather; Adverse Effect →
Kidney Dysfunction — all drugs for Kidney Dysfunction →
Kidney Injury — all drugs for Kidney Injury →
Hyperthermia — all drugs for Hyperthermia →

Sponsor

Indiana University

Who can join

Adults 18 to 44, any sex, with Hot Weather; Adverse Effect or Kidney Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration. The current heat stress recommendations for workers were not developed with regards for kidney health. The purpose of this study is to determine if the current recommendations protect against kidney dysfunction.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Ad libitum drinking prevents dehydration during physical work in the heat when adhering to occupational heat stress recommendations.
Hess HW, Tarr ML, Baker TB, Hostler D, et al · · 2022 · cited 10× · PMID 36211944 · DOI 10.1080/23328940.2022.2094160
Occupational Heat Stress Recommendation Compliance Attenuates AKI Risk Compared with a Work-Rest Ratio-Matched, Positive Control Scenario.
Hess HW, Baker TB, Tarr ML, Zoh RS, et al · · 2023 · cited 9× · PMID 37907448 · DOI 10.34067/kid.0000000000000288
Creatinine clearance is maintained in a range of wet-bulb globe temperatures and work-rest ratios during simulated occupational heat stress.
Hess HW, Baker TB, Tarr ML, Zoh RS, et al · · 2024 · cited 3× · PMID 38867674 · DOI 10.1152/ajprenal.00089.2024
Influence of work intensity on acute kidney injury risk during simulated occupational heat stress.
Hess HW, Heikkinen ME, Tourula E, Hite MJ, et al · · 2025 · cited 2× · PMID 39855252 · DOI 10.1152/japplphysiol.00590.2024
Critical Assessment of the Recommended Alert Limit Curves for Occupational Heat Exposure.
Hess HW, Hite MJ, Heikkinen ME, Tarr ML, et al · · 2025 · cited 1× · PMID 40914830 · DOI 10.1002/ajim.70022

Verify or expand the search:

Other recruiting trials for Hot Weather; Adverse Effect

Currently open trials in the same condition.

NCT06982339 — Beat the Heat Boston · NA · recruiting

Other Indiana University trials

Trials by the same sponsor.

NCT07470086 — The Role of Environmental Temperatures in Respiratory Control · NA · not yet recruiting
NCT07470099 — The Role of Breathing Perception in Respiratory Control · NA · not yet recruiting
NCT07179952 — Efficacy and Safety of Slow Release Dehydroepiandrosterone (DHEA ) · Phase 2 · not yet recruiting
NCT07070804 — Maternal Biomarkers and Environmental Contributors to Autism Spectrum Disorders in Children of First-time Mothers · not yet recruiting
NCT07499583 — Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder · Phase 1, PHASE2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04767347 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Indiana University
Last refreshed: 8 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04767347.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing