NCT04758910 is a NA clinical trial of High Flow Oxygen Therapy in Weaning Failure, sponsored by Evangelismos Hospital.

Who is sponsoring NCT04758910?

NCT04758910 is sponsored by Evangelismos Hospital.

What drugs are being tested in NCT04758910?

Interventions in NCT04758910: High Flow Oxygen Therapy, T-piece.

What condition does NCT04758910 study?

NCT04758910 studies Weaning Failure.

Is NCT04758910 still recruiting?

NCT04758910 is currently status unknown. Last updated 17 February 2021.

Last reviewed 2021-02-17 · How we verify

NCT04758910

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function

Status unknown NA Last updated 17 February 2021

What this trial tests

NA trial testing High Flow Oxygen Therapy in Weaning Failure in 30 participants. Status unknown.

Timeline

1 March 2021

Primary endpoint
30 May 2021

30 July 2021

Quick facts

Lead sponsor	Evangelismos Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	1 March 2021
Primary completion	30 May 2021
Estimated completion	30 July 2021

Drugs / interventions tested

High Flow Oxygen Therapy
T-piece

Conditions studied

Weaning Failure — all drugs for Weaning Failure →

Sponsor

Evangelismos Hospital

Who can join

18 and older, any sex, with Weaning Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

While the high flow oxygen therapy (HFOT) respiratory support system, delivered through nasal cannulas, has demonstrated clinical benefits on respiratory function, limited data exist on whether such effects are also present in HFOT through tracheostomy. Therefore, the aim of the proposed study is to examine the short-term effects of HFOT as opposed to oxygen therapy via T-piece on diaphragmatic function in tracheostomized patients with prolonged weaning from mechanical ventilation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The effect of high-flow oxygen via tracheostomy on respiratory pattern and diaphragmatic function in patients with prolonged mechanical ventilation: A randomized, physiological, crossover study.
Lytra E, Kokkoris S, Poularas I, Filippiadis D, et al · · 2024 · cited 5× · PMID 38681788 · DOI 10.1016/j.jointm.2023.11.008

Verify or expand the search:

Other trials of High Flow Oxygen Therapy

Trials testing the same drug.

NCT05196698 — Home High Flow Oxygen to Reduce Acute Exacerbation of COPD · NA · recruiting

Other recruiting trials for Weaning Failure

Currently open trials in the same condition.

NCT07105202 — Shorter Weaning From Invasive Ventilation With Levosimendan · Phase 4 · recruiting
NCT07003672 — Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostom · recruiting
NCT06683781 — Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients · recruiting
NCT06754670 — Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning · recruiting
NCT06592144 — TESTO-TRIAL: Use of Testosterone in Critically Ill Patients · Phase 4 · active not recruiting

Other Evangelismos Hospital trials

Trials by the same sponsor.

NCT07082569 — Effect of Ventilation Mode in the Pupillary Light Reflex: A Crossover Study · NA · not yet recruiting
NCT06707623 — CPET Guided Rehab vs Physiotherapy in Patients With Dysfunctional Breathing · NA · recruiting
NCT06221995 — Energy Expenditure in Patients With Ulcerative Colitis Undergoing Surgery · active not recruiting
NCT05855356 — Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial · NA · unknown
NCT05464277 — Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain Injury · NA · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04758910 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Evangelismos Hospital
Last refreshed: 17 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04758910.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing