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NCT04754763
A Comparative Study On The Effect Of Propolis And Dentine Bonding Agent In Treating Dentine Hypersensitivity
EARLY_PHASE1 trial testing Dentin-Bonding Agents in Dentine Hypersensitivity in 52 participants. Completed in 30 July 2019.
31 May 2019
Quick facts
| Lead sponsor | Dow University of Health Sciences |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 52 |
| Start date | 1 June 2018 |
| Primary completion | 31 May 2019 |
| Estimated completion | 30 July 2019 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Dentin-Bonding Agents — full drug profile →
- Propolis — full drug profile →
Conditions studied
- Dentine Hypersensitivity — all drugs for Dentine Hypersensitivity →
Sponsor
Dow University of Health Sciences
Who can join
Adults 20 to 45, any sex, with Dentine Hypersensitivity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Dentine hypersensitivity (DH) causes considerable pain and discomfort to an individual due to number of stimuli on exposed dentine. Different kinds of treatment strategies are used in the resolution of dentine hypersensitivity including the use of propolis and dentine bonding agent. No study had compared the efficacy of propolis and dentine bonding agent. Objective: The objective of the study was to find out whether there is a difference in the efficacy of Propolis and seventh generation dentine bonding agent in reducing the dentine hypersensitivity. Comparison within the groups and pairwise comparisons were also recorded in reducing dentine hypersensitivity. Methods: In this six month In- Vivo single blinded randomized clinical study, a total number of 52 patients with complain of dentine hypersensitivity were selected in two groups after taking informed consent. Group A and B received 30% ethanolic extract of propolis and dentine bonding agents respectively by a trained operator. Recordings of dentine hypersensitivity were obtained at Day 0, before and after the application of experimental agents, and also on Day 7, 15 and 30 by the principal investigator. Response was measured by Visual Analog Scale and Schiff Cold Air Sensitivity Scale. Statistical Package for the Social Sciences (SPSS) version 20 was used to analyze the data with level of significance set at p \< 0.05. Friedman test was applied to see the comparison within groups and Wilcoxon Signed Rank test was used for Pairwise comparison. Mann Whitney U-Test was applied for comparison between groups.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04754763
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Related trials
Other recruiting trials for Dentine Hypersensitivity
Currently open trials in the same condition.
- NCT06633627 — Neurological Responses in Patients with Dentine Hypersensitivity · recruiting
Other Dow University of Health Sciences trials
Trials by the same sponsor.
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- NCT07433374 — COMPARISON OF THE EFFICIENCY OF MANUAL SINGLE HEADED AND TRIPLE HEADED TOOTHBRUSHES IN REMOVING DENTAL PLAQUE AND USER E · NA · completed
- NCT07277621 — Behavioral Interventions to Reduce Social Media Addiction Among School-Going Adolescents in Karachi · NA · completed
- NCT07323771 — Improving Oral Health Knowledge and Habits in People With Diabetes Through a Theory Guided WhatsApp Education Program · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04754763 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dow University of Health Sciences
- Last refreshed: 15 February 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04754763.
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