18 and older, any sex, with Covid19 or Appendicitis. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Number of Participants With Pulmonary ComplicationsPrimary· Up to 90 days
Including pneumonia, acute respiratory distress syndrome (ARDS) or unexpected postoperative ventilation
For operative management this means any episode of non-invasive ventilation, invasive ventilation, or extracorporeal membrane oxygenation after initial extubation after surgery, or patient cannot be extubated as planned after surgery.
For non-operative management this means any intubation
Group
Value
95% CI
Operative Management
0
Non-operative Management
0
Number of Participants With Post-intervention ICU AdmissionSecondary· Up to 90 days
ICU admission following randomization
Group
Value
95% CI
Operative Management
0
Non-operative Management
0
Mortality (All Cause)Secondary· Up to 90 days
Any death
Group
Value
95% CI
Operative Management
0
Non-operative Management
0
Complications as Measured by the Clavien-Dindo ClassificationSecondary· Up to 90 days
The Clavien-Dindo classification is a grading scale from 1 to 5 (with 5 being more severe0 to objectively describe the severity of a complication, including any deviation from the normal postoperative course
Group
Value
95% CI
Non-operative Management
1
Median Length of Hospital StaySecondary· Up to 90 days
Cumulative and individual length of hospitalization(s)
Group
Value
95% CI
Operative Management
44
Non-operative Management
137
Number of Emergency Room Visits/ReadmissionSecondary· Up to 90 days
Group
Value
95% CI
Operative Management
0
Non-operative Management
0
Number of Participants With Treatment Failure for Non-operative ManagementSecondary· Up to 90 days
Patients randomized to non-operative management who require non-elective surgery to remove the affected organ
Group
Value
95% CI
Non-Operative Management
0
Sponsor's own description
This study evaluates operative and non-operative management of acute appendicitis (infection or inflammation of the appendix) and acute cholecystitis (inflammation/infection of the gallbladder) in patients with active mild to moderate COVID-19 infection. The hypothesis is that COVID+ patients with uncomplicated acute appendicitis or acute cholecystitis amendable to a laparoscopic procedure can have safe operative outcomes compared to those managed non-operatively.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
NCT04168866 — Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon
· NA
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 14 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04748120.