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NCT04168866
Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon
NA trial testing Operative management in Appendicitis in 180 participants. Currently enrolling.
31 December 2028
Quick facts
| Lead sponsor | Yale University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 180 |
| Start date | 11 March 2020 |
| Primary completion | 31 December 2028 |
| Estimated completion | 31 December 2029 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Operative management
- Drainage or antibiotics
Conditions studied
- Appendicitis — all drugs for Appendicitis →
Sponsor
Yale University
Who can join
18 and older, any sex, with Appendicitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04168866
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Operative management
Trials testing the same drug.
- NCT04748120 — Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients · NA · terminated
Other recruiting trials for Appendicitis
Currently open trials in the same condition.
- NCT07115303 — Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure · NA · recruiting
- NCT06395636 — Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients · NA · recruiting
- NCT07049965 — Comparative Study of Harmonic Scalpel vs. Suture Ligation for Appendix Base During Laparoscopic Appendectomy · NA · active not recruiting
- NCT07478029 — Clinical Study of PEG Bowel Preparation in Appendectomy Patients · recruiting
- NCT06177418 — Transumbilical Laparoscopic Appendectomy · NA · recruiting
Other Yale University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04168866 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yale University
- Last refreshed: 29 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04168866.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing