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NCT04742686: ATAS
Aerobic Exercise Training in Acute Ischaemic Stroke
NA trial testing Aerobic exercise training in Ischemic Stroke in 30 participants. Completed in 25 August 2022.
25 August 2022
Quick facts
| Lead sponsor | Sheffield Hallam University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 30 |
| Start date | 27 April 2021 |
| Primary completion | 25 August 2022 |
| Estimated completion | 25 August 2022 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Aerobic exercise training
Conditions studied
- Ischemic Stroke — all drugs for Ischemic Stroke →
- Acute Stroke — all drugs for Acute Stroke →
- Cerebrovascular Accident — all drugs for Cerebrovascular Accident →
Sponsor
Sheffield Hallam University
Who can join
18 and older, any sex, with Ischemic Stroke or Acute Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Stroke is a leading cause of adult disability in the UK. There are few treatment options that improve long-term disability outcomes after stroke. Animal studies indicate that aerobic exercise training can improve brain repair and reduce disability after stroke. However, in clinical practice it is difficult for stroke survivors to undertake aerobic exercise due to lower-limb disability and a lack of accessible exercise equipment. This study will assess the feasibility of implementing a 5-day aerobic exercise training intervention, beginning in the acute phase of stroke (1-7 days post-stroke), using a power-assisted exercise bike. Feasibility outcome measures: recruitment rate (30 participants recruited within 18 months), completeness of data (\>80% of planned measurements recorded) and the safety (\<10 adverse events related to the intervention) and acceptability (\>3/5 comfort scale) of the intervention. We will also investigate the acute effects of aerobic exercise on cerebral blood flow velocity using transcranial Doppler ultrasound, and brain-derived neurotrophic factor (serum and plasma).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
ESOC 2023 Abstract Book
· 2023
Verify or expand the search:
- PubMed search for NCT04742686
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for Ischemic Stroke
Currently open trials in the same condition.
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- NCT07375953 — Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK) · Phase 2 · recruiting
- NCT07375966 — Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours · Phase 2 · recruiting
- NCT07491952 — Continuous Dual Aspiration Technique With Zoom System for Stroke · recruiting
- NCT07371455 — A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants · Phase 1 · recruiting
Other Sheffield Hallam University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04742686 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sheffield Hallam University
- Last refreshed: 21 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04742686.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing