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NCT05756075: ADAPT

The ADAPT-study: Measuring Physical Performance Using Wearable Sensors in Parkinson's Disease and COPD (ADAPT)

Completed Results posted Last updated 12 March 2025
What this trial tests

trial testing Aerobic exercise training in Parkinson Disease in 154 participants. Completed in 30 November 2023.

Timeline
23 December 2021
Primary endpoint
30 November 2023
30 November 2023

Quick facts

Lead sponsorRadboud University Medical Center
StatusCompleted
Study typeOBSERVATIONAL
Enrollment154
Start date23 December 2021
Primary completion30 November 2023
Estimated completion30 November 2023
Sites28 locations across Netherlands

Drugs / interventions tested

Conditions studied

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Parkinson Disease or COPD. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Mean Difference in Distance Walked During 6MWT Primary · Week 0, week 5, week 10 and week 15

Mean difference in distance walked during the 6MWT (6MWD) derived from the Verily Study Watch and clinician measured distance. Note: reported outcome is the mean difference in 6MWD between week 0 and week 15 and is determined as the difference between the two clincian measured distances. The walking distance derived from the Verily Study Watch needs to be determined, this is work in progress

GroupValue95% CI
Parkinson's Disease33± 8
COPD15± 10
Change in Physical Capacity Secondary · Week 5 until week 15

Change in 6MWD from week 5 until week 15 after aerobic exercise capacity training

GroupValue95% CI
Parkinson's Disease-17.1± 120.7
COPD-15.4± 89.1
Change in Gait Speed (10MWT) Secondary · Week 0, Week 5, Week 10, Week 15

The difference in time to complete the 10MWT with and without cognitive task while walking and over time

Week 0
GroupValue95% CI
Parkinson's Disease-1.3± 2.3
COPD-1.0± 1.9
Week 5
GroupValue95% CI
Parkinson's Disease-1.2± 2.1
COPD-0.56± 0.6
Week 10
GroupValue95% CI
Parkinson's Disease-1.3± 1.9
COPD-0.4± 0.5
Week 15
GroupValue95% CI
Parkinson's Disease-1.2± 1.8
COPD-0.7± 1.8
Change in Cognition (MoCA) Secondary · Week 0 and Week 15

Change from baseline on the Montreal Cognitive Assessment (MoCA) score at 15 weeks. Range 0-30. Higher scores indicate better cognition

Week 0
GroupValue95% CI
Parkinson's Disease25.9± 3.8
COPD25.7± 2.7
Week 15
GroupValue95% CI
Parkinson's Disease26.1± 3.8
COPD25.2± 2.8
Change in Parkinson's Disease Symptoms (MDS-UPDRS) Secondary · Week 0, Week 5, Week 10, Week 15

Change from baseline in the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS) at week 5, week 10 and week 15. Range 0-199. Higher scores indicate worse function. note: only the difference in score between week 0 and week 15 is reported

GroupValue95% CI
Parkinson's Disease4.5± 19.2
Change in Depression and Anxiety (HADS) Secondary · Week 0, Week 5, Week 10, Week 15

Change from baseline on the Hospital Anxiety and Depression Scale (HADS) at week 5, week 10 and week 15. Range 0-42. Higher scores indicate worse function Note: only the difference between week 0 and week 15 is reported

GroupValue95% CI
Parkinson's Disease0.6± 3.6
COPD0.7± 3.7
Change in Health Related Quality of Life (PDQ-39) Secondary · Week 0, Week 5, Week 10, Week 15

Change from baseline on the Health related quality of life (PDQ-39) questionnaire at week 5, week 10 and week 15. Range 0-100. HIgher scores indicate better function Note: only the difference between week 0 and week 15 is reported

GroupValue95% CI
Parkinson's Disease0.88± 15.3
Clinical COPD Questionnaire (CCQ) Secondary · Week 0, Week 5, Week 10, Week 15

Assessment of and change in health related quality of life from baseline and at week 5, week 10 and week 15. Range 0-60. Higher scores indicate worse function

Week 0
GroupValue95% CI
COPD22 – 2
Week 5
GroupValue95% CI
COPD21 – 2
Week 10
GroupValue95% CI
COPD21 – 2
Week 15
GroupValue95% CI
COPD21 – 2
Medical Research Council Dyspnea (mMRC) Secondary · Week 0, Week 5, Week 10, Week 15

Assessment of dyspnea severity at baseline, week 5, week 10 and week 15. Range 0-4. Higher scores indicate worse function This test is only completed by the COPD participants as it is a COPD-specific questionnaire.

Week 0
GroupValue95% CI
COPD32 – 3
Week 5
GroupValue95% CI
COPD32 – 3
Week 10
GroupValue95% CI
COPD32 – 3
Week 15
GroupValue95% CI
COPD32 – 3

Adverse events — posted to ClinicalTrials.gov

Time frame: Adverse event data were collected from baseline to study completion. Reporting threshold: 2%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Parkinson's Disease
Serious: 0/89 (0%)
Deaths: 0/89
COPD
Serious: 1/65 (2%)
Deaths: 1/65

Serious adverse events (1 terms)

ReactionSystemParkinson's DiseaseCOPD
Lung cancer stage 4 diagnosisRespiratory, thoracic and mediastinal disorders

Most-reported serious reactions: Lung cancer stage 4 diagnosis.

Data from ClinicalTrials.gov NCT05756075 adverse events section.

Sponsor's own description

The aim of this study is to investigate whether a smartwatch can measure the physical capacity of patients with Parkinson's Disease and COPD in the physiotherapy practice and at home.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Measuring Physical Functioning Using Wearable Sensors in Parkinson Disease and Chronic Obstructive Pulmonary Disease (the Accuracy of Digital Assessment of Performance Trial Study): Protocol for a Prospective Observational Study.
    de Graaf D, de Vries NM, van de Zande T, Schimmel JJP, et al · · 2024 · cited 1× · PMID 38713508 · DOI 10.2196/55452
  2. Synaptic Plasticity in Neurodegenerative Diseases: Impact of Exercise as Promising Therapeutic Tool.
    Farina G, Fenili G, Paronetto MP, Crescioli C. · · 2026 · PMID 41597271 · DOI 10.3390/cells15020197

Verify or expand the search:

Other trials of Aerobic exercise training

Trials testing the same drug.

Other recruiting trials for Parkinson Disease

Currently open trials in the same condition.

Other Radboud University Medical Center trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05756075.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing