NCT04737980 is a Phase 4 clinical trial of Liposomal bupivacaine in Rotator Cuff Tears, sponsored by Hospital for Special Surgery Florida.

Who is sponsoring NCT04737980?

NCT04737980 is sponsored by Hospital for Special Surgery Florida.

What drugs are being tested in NCT04737980?

Interventions in NCT04737980: Liposomal bupivacaine, Bupivacaine Hcl 0.5% Inj, Ropivacaine 0.5% Injectable Solution, Dexamethasone.

What condition does NCT04737980 study?

NCT04737980 studies Rotator Cuff Tears, Shoulder Pain.

Is NCT04737980 still recruiting?

NCT04737980 is currently completed. Last updated 8 February 2021.

Last reviewed 2021-02-08 · How we verify

NCT04737980

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair

Completed Phase 4 Last updated 8 February 2021

What this trial tests

Phase 4 trial testing Liposomal bupivacaine in Rotator Cuff Tears in 92 participants. Completed in 18 March 2020.

Timeline

18 July 2019

Primary endpoint
28 February 2020

18 March 2020

Quick facts

Lead sponsor	Hospital for Special Surgery Florida
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	92
Start date	18 July 2019
Primary completion	28 February 2020
Estimated completion	18 March 2020
Sites	1 location across United States

Drugs / interventions tested

Liposomal bupivacaine — full drug profile →
Bupivacaine Hcl 0.5% Inj — full drug profile →
Ropivacaine 0.5% Injectable Solution — full drug profile →
Dexamethasone (dexamethasone) — full drug profile →

Conditions studied

Rotator Cuff Tears — all drugs for Rotator Cuff Tears →
Shoulder Pain — all drugs for Shoulder Pain →

Sponsor

Hospital for Special Surgery Florida

Who can join

18 and older, any sex, with Rotator Cuff Tears or Shoulder Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a comparison of analgesia effect from peripheral nerve blockade (PNB) with liposomal bupivacaine combined with bupivacaine compared to PNB with ropivacaine combined with dexamethasone for arthroscopic rotator cuff repair.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Liposomal Bupivacaine Plus Bupivacaine Versus Ropivacaine Plus Dexamethasone Brachial Plexus Blockade for Arthroscopic Rotator Cuff Repair: An Unblinded Randomized Controlled Trial.
Simovitch RW, Hernandez T, YaDeau JT, Grant MC, et al · · 2022 · cited 4× · PMID 36147653 · DOI 10.2106/jbjs.oa.21.00122

Verify or expand the search:

Other trials of Liposomal bupivacaine

Trials testing the same drug.

NCT06704698 — Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery · NA · recruiting
NCT06575699 — Rectus Sheath Block for Analgesia After Gynecological Laparotomy · Phase 4 · completed
NCT06575010 — Exparel v Dexamethasone in RCR · Phase 4 · enrolling by invitation
NCT06569953 — Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chron · Phase 4 · recruiting
NCT06405724 — Comparison of the Ultrasound-guided Paravertebral Nerve Block With Liposomal Bupivacaine Versus Ropivacaine for Post-Sur · Phase 3 · not yet recruiting

Other recruiting trials for Rotator Cuff Tears

Currently open trials in the same condition.

NCT07383038 — Effect of Mobilization With Movement in Patients With Rotator Cuff Lesions · NA · recruiting
NCT06918041 — FiberLocker® System Augmentation of Rotator Cuff Repairs · NA · recruiting
NCT06886932 — Pain Education After Rotator Cuff Surgery · recruiting
NCT07001566 — The Impact of Cervical Radiculopathy on Functionality in Patients Undergoing Rotator Cuff Repair · recruiting
NCT06733480 — Innovating Physical Therapy: A Pilot Study on Band Connect's Impact on Compliance, Satisfaction, and Revenue · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04737980 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital for Special Surgery Florida
Last refreshed: 8 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04737980.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing