NCT04732793 is a NA clinical trial of Hyruan ONE® in Osteoarthritis (OA) of the Knee, sponsored by LG Chem.

Who is sponsoring NCT04732793?

NCT04732793 is sponsored by LG Chem.

What drugs are being tested in NCT04732793?

Interventions in NCT04732793: Hyruan ONE®, Durolane®.

What condition does NCT04732793 study?

NCT04732793 studies Osteoarthritis (OA) of the Knee.

Is NCT04732793 still recruiting?

NCT04732793 is currently completed. Last updated 16 March 2022.

Last reviewed 2022-03-16 · How we verify

NCT04732793

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

To Assess the Safety and Effectiveness of Hyruan ONE Versus a Comparator for the Treatment of Knee Osteoarthritis in Europe

Completed NA Last updated 16 March 2022

What this trial tests

NA trial testing Hyruan ONE® in Osteoarthritis (OA) of the Knee in 284 participants. Completed in 7 December 2021.

Timeline

3 February 2021

Primary endpoint
11 June 2021

7 December 2021

Quick facts

Lead sponsor	LG Chem
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	284
Start date	3 February 2021
Primary completion	11 June 2021
Estimated completion	7 December 2021
Sites	1 location across Poland

Drugs / interventions tested

Hyruan ONE®
Durolane®

Conditions studied

Osteoarthritis (OA) of the Knee — all drugs for Osteoarthritis (OA) of the Knee →

Sponsor

LG Chem — full company profile →

Who can join

40 and older, any sex, with Osteoarthritis (OA) of the Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To Assess the Safety and Effectiveness of Hyruan ONE versus a Comparator for the Treatment of Knee Osteoarthritis in Europe

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Efficacy and Safety of Intra-Articular Cross-Linked Sodium Hyaluronate for the Treatment of Knee Osteoarthritis: A Prospective, Active-Controlled, Randomized, Parallel-Group, Double-Blind, Multicenter Study.
Blicharski T, Łukasik P, Plebanski R, Żęgota Z, et al · · 2023 · cited 6× · PMID 37109318 · DOI 10.3390/jcm12082982

Verify or expand the search:

Other recruiting trials for Osteoarthritis (OA) of the Knee

Currently open trials in the same condition.

NCT07231471 — Platelet Rich Plasma for Musculoskeletal Conditions · NA · recruiting
NCT06929871 — Mako Cementless TKA vs Mako Cemented TKA · NA · recruiting
NCT06865079 — 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femo · Phase 2 · active not recruiting
NCT06702046 — The Efficacy of Transcutaneous Pulsed Radiofrequency Acupuncture for Knee Osteoarthritis · NA · recruiting
NCT06805188 — Clinical Study of Acupuncture Treatment of Knee Osteoarthritis · NA · recruiting

Other LG Chem trials

Trials by the same sponsor.

NCT07396844 — The Food Effect on Pharmacokinetics of Fixed Dose Combination of Gemigliptin/Dapagliflozin/Metformin in Healthy Voluntee · Phase 1 · not yet recruiting
NCT07399470 — A Clinical Study in Healthy Adults to See How the Body Processes and How Safe a Tablet That Combines Gemigliptin, Dapagl · Phase 1 · active not recruiting
NCT07333742 — A Clinical Study to See How the Body Handles and How Safe a Combination Tablet of Gemigliptin, Dapagliflozin, and Metfor · Phase 1 · completed
NCT06921395 — Phase IV Study to Evaluate the Efficacy and Safety of Fang Le Shu Compared to Guo Na Fen for Controlled Ovarian Stimulat · Phase 4 · recruiting
NCT06743997 — A Study to Compare Eutropin Formulations in Healthy Volunteers for Bioavailability, Safety, and Tolerability · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04732793 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by LG Chem
Last refreshed: 16 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04732793.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing