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NCT04720248
Postoperative Pain in Scheduled Craniotomy
trial testing Metamizole in Pain, Postoperative in 73 participants. Completed in 15 August 2021.
30 June 2021
Quick facts
| Lead sponsor | Dr. Negrin University Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 73 |
| Start date | 24 February 2021 |
| Primary completion | 30 June 2021 |
| Estimated completion | 15 August 2021 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Metamizole (METAMIZOLE) — full drug profile →
Conditions studied
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Craniotomy — all drugs for Craniotomy →
- Adverse Effect — all drugs for Adverse Effect →
- Anxiety — all drugs for Anxiety →
Sponsor
Dr. Negrin University Hospital
Who can join
18 and older, any sex, with Pain, Postoperative or Craniotomy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative pain after craniotomy is frequent, with moderate-severe intensity. The fear to the side effects of opioids (nausea and vomiting and sedation), and NSAIDs (bleeding) makes it difficult to obtain adequate analgesic control in these patients. Preoperative anxiety may be associated with a poorer postoperative analgesic control, hindering the adequate postoperative evolution and increasing hospital stay and adverse effects. In this observational study, the investigators aimed to assess the postoperative analgesic management in patients undergoing scheduled craniotomy following routine clinical practice and to relate preoperative anxiety with the postoperative analgesic evaluation in this population.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of Preoperative Anxiety on Postoperative Pain after Craniotomy.
Valencia L, Becerra Á, Ojeda N, Domínguez A, et al · · 2022 · cited 15× · PMID 35160007 · DOI 10.3390/jcm11030556
Verify or expand the search:
- PubMed search for NCT04720248
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Dr. Negrin University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04720248 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dr. Negrin University Hospital
- Last refreshed: 18 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04720248.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing