NCT04706897 is a Phase 4 clinical trial of Dexmedetomidine, ketamine and lidocaine in PONV, sponsored by Tanta University.

Who is sponsoring NCT04706897?

NCT04706897 is sponsored by Tanta University.

What drugs are being tested in NCT04706897?

Interventions in NCT04706897: Dexmedetomidine, ketamine and lidocaine, Normal saline.

What condition does NCT04706897 study?

NCT04706897 studies PONV, Opioid Sparing Anaesthesia.

Is NCT04706897 still recruiting?

NCT04706897 is currently completed. Last updated 28 May 2021.

Last reviewed 2021-05-28 · How we verify

NCT04706897

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery

Completed Phase 4 Last updated 28 May 2021

What this trial tests

Phase 4 trial testing Dexmedetomidine, ketamine and lidocaine in PONV in 80 participants. Completed in 26 May 2021.

Timeline

15 January 2021

Primary endpoint
25 May 2021

26 May 2021

Quick facts

Lead sponsor	Tanta University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	80
Start date	15 January 2021
Primary completion	25 May 2021
Estimated completion	26 May 2021
Sites	1 location across Egypt

Drugs / interventions tested

Dexmedetomidine, ketamine and lidocaine — full drug profile →
Normal saline

Conditions studied

PONV — all drugs for PONV →
Opioid Sparing Anaesthesia — all drugs for Opioid Sparing Anaesthesia →

Sponsor

Tanta University

Who can join

Adults 21 to 60, female only, with PONV or Opioid Sparing Anaesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and vomiting (PONV) are still common complaints reported after laparoscopic gynecological surgery. So, it is hypothesized that the infusion consisting of lidocaine, dexmedetomidine and ketamine, as an opioid substitute was a feasible technique for laparoscopic gynecological surgery and would be associated with less incidence of PONV and lower opioid requirements in the early postoperative period. The aim of this study was to evaluate the effect of opioid sparing technique via infusion of Dexmedetomidine, Ketamine and Lidocaine on post-operative nausea and vomiting in laparoscopic gynecological surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for PONV

Currently open trials in the same condition.

NCT07515027 — Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung · NA · recruiting
NCT07176676 — Aromatherapy Treatment With Lavender Essential Oil to Reduce Post-Operative Nausea and Vomiting (PONV) · NA · active not recruiting
NCT07051109 — Dual-chamber Patient-controlled Analgesia for Postoperative Recovery · NA · recruiting
NCT03783182 — Betamethasone (Betapred®) as Premedication for Reducing Postoperative Vomiting and Pain After Tonsillectomy · Phase 4 · recruiting
NCT03187535 — Effect of TEAS on PONV After Spinal Surgery · NA · recruiting

Other Tanta University trials

Trials by the same sponsor.

NCT07398651 — Apremilast and Adalimumab in Psoriatic Arthritis Patients · NA · not yet recruiting
NCT06966856 — This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcti · Phase 3 · not yet recruiting
NCT07334197 — Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy · NA · not yet recruiting
NCT07498998 — Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome · NA · not yet recruiting
NCT07114250 — Comparative Study Between Spinal Anesthesia Versus General Anesthesia in Supine Percutaneous Nephrolithotomy Operation · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04706897 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tanta University
Last refreshed: 28 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04706897.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing