Last reviewed · How we verify
NCT04706767
Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery
NA trial testing Co-administration Lidocaine and Dexmedetomidine in Lidocaine in 160 participants. Completed in 25 June 2021.
25 June 2021
Quick facts
| Lead sponsor | Anqing Municipal Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 160 |
| Start date | 28 January 2021 |
| Primary completion | 25 June 2021 |
| Estimated completion | 25 June 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- Co-administration Lidocaine and Dexmedetomidine — full drug profile →
- Dexmedetomidine infusion
- Lidocaine infusion — full drug profile →
- Saline infusion — full drug profile →
Conditions studied
- Lidocaine — all drugs for Lidocaine →
- Dexmedetomidine — all drugs for Dexmedetomidine →
- Quality of Recovery(QoR-40), Preoperative and Postoperative — all drugs for Quality of Recovery(QoR-40), Preoperative and Postoperative →
Sponsor
Anqing Municipal Hospital
Who can join
Eligibility, female only, with Lidocaine or Dexmedetomidine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
BACKGROUND: Some studies have revealed that intravenous (IV) lidocaine or dexmedetomidine might improve the quality of recovery undergoing laparoscopic surgery. The investigators investigated whether co-administration lidocaine and dexmedetomidine could better improve the the quality of recovery after laparoscopic total hysterectomy. METHODS: One hundred and forty-four women with elective laparoscopic total hysterectomy were randomly divided into four groups: Patients in group L received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close the pneumoperitoneum. Patients in group D received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close the pneumoperitoneum. Patients in group LD received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close the pneumoperitoneum, respectively. Patients in group C received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close the pneumoperitoneum. Primary outcome was the quality of recovery (QoR-40) at 1 day prior to sugery, 1 day after sugery, and 2 days after sugery. The secondary outcomes included perioperative remifentanil consumption, postoperative VAS scores, the incidence of postoperative nausea and vomiting, postoperative rescue analgesics and anti-emetics, recovery time, extubation time, and Ramsay sedation scale at 5 min, 10min, 30 min, 60 min after extubation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04706767
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Lidocaine
Currently open trials in the same condition.
- NCT07327905 — Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy · NA · recruiting
- NCT07108764 — Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative · NA · recruiting
- NCT06910644 — Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastecto · NA · recruiting
- NCT06848764 — Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery · NA · recruiting
- NCT06837519 — Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted · NA · recruiting
Other Anqing Municipal Hospital trials
Trials by the same sponsor.
- NCT07062601 — Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children · NA · not yet recruiting
- NCT06952309 — Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat · NA · not yet recruiting
- NCT06990893 — Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Su · NA · recruiting
- NCT06967896 — Different Models of Tracheal Catheters Are Used for Female Thyroid Glands · recruiting
- NCT06469866 — Deep Neuromuscular Block Affect the Quality of Recovery After Laparoscopic Hysterectomy · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04706767 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Anqing Municipal Hospital
- Last refreshed: 10 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04706767.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing