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lidocaine infusion
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia, Neuropathic pain, Cardiac arrhythmias (ventricular).
At a glance
| Generic name | lidocaine infusion |
|---|---|
| Also known as | Lignocaine, 2% lidocaine hydrochloride, Lidocaine hydrochloride, Preservative Free Lidocaine Hydrochloride, xylocaine iv |
| Sponsor | Medical University of Warsaw |
| Drug class | Local anesthetic / Sodium channel blocker |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management, Cardiology |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. When administered as an infusion, it can provide systemic analgesic and anti-inflammatory effects, particularly for neuropathic pain and certain arrhythmias.
Approved indications
- Local anesthesia
- Neuropathic pain
- Cardiac arrhythmias (ventricular)
Common side effects
- Dizziness
- Lightheadedness
- Tremor
- Perioral numbness
- Tinnitus
- Cardiac arrhythmias (at high doses)
- Hypotension
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Intravenous Lidocaine Infusion in Lumbar Fusion Surgery (NA)
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lidocaine infusion CI brief — competitive landscape report
- lidocaine infusion updates RSS · CI watch RSS
- Medical University of Warsaw portfolio CI