Who is sponsoring NCT04698005?

NCT04698005 is sponsored by Institute for Clinical and Experimental Medicine.

What drugs are being tested in NCT04698005?

Interventions in NCT04698005: 25g Ketone monoester without added salts, Placebo.

What condition does NCT04698005 study?

NCT04698005 studies Acute Heart Failure, Low Cardiac Output Syndrome, Hemodynamic Instability, Ketosis.

Is NCT04698005 still recruiting?

NCT04698005 is currently status unknown. Last updated 6 January 2021.

Last reviewed 2021-01-06 · How we verify

NCT04698005: KADHEF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Exogenous Ketones for Acutely Decompensated HEart Failure

Status unknown Phase 3 Last updated 6 January 2021

What this trial tests

Phase 3 trial testing 25g Ketone monoester without added salts in Acute Heart Failure in 24 participants. Status unknown.

Timeline

2 December 2020

Primary endpoint
31 December 2021

31 December 2021

Quick facts

Lead sponsor	Institute for Clinical and Experimental Medicine
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	24
Start date	2 December 2020
Primary completion	31 December 2021
Estimated completion	31 December 2021
Sites	1 location across Czechia

Drugs / interventions tested

25g Ketone monoester without added salts
Placebo

Conditions studied

Acute Heart Failure — all drugs for Acute Heart Failure →
Low Cardiac Output Syndrome — all drugs for Low Cardiac Output Syndrome →
Hemodynamic Instability — all drugs for Hemodynamic Instability →
Ketosis — all drugs for Ketosis →

Sponsor

Institute for Clinical and Experimental Medicine

Who can join

18 and older, any sex, with Acute Heart Failure or Low Cardiac Output Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will evaluate whether supplementation of exogenous ketones in patients with severe left ventricular dysfunction and acutely decompensated heart failure requiring inotropic therapy would improve the patient's hemodynamics and symptoms.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond.
Sun Q, Karwi QG, Wong N, Lopaschuk GD. · · 2024 · cited 55× · PMID 39453987 · DOI 10.1093/cvr/cvae231
The therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle.
Soni S, Tabatabaei Dakhili SA, Ussher JR, Dyck JRB. · · 2024 · cited 18× · PMID 38193855 · DOI 10.1152/ajpcell.00501.2023

Verify or expand the search:

Other recruiting trials for Acute Heart Failure

Currently open trials in the same condition.

NCT06587854 — a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure · recruiting
NCT07008365 — The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure · Phase 3 · recruiting
NCT06465498 — Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography · NA · recruiting
NCT06597331 — Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital · recruiting
NCT06166654 — Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Phase 4 · recruiting

Other Institute for Clinical and Experimental Medicine trials

Trials by the same sponsor.

NCT07536087 — Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumor · NA · recruiting
NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07326826 — Hernia Repair Using Rectus Fascia Allograft · not yet recruiting
NCT06872255 — Per-oral Endoscopic Myotomy (POEM) in Patients with Postfundplication Dysphagia · NA · not yet recruiting
NCT07153432 — Chronic Kidney Disease Screening · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04698005 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Institute for Clinical and Experimental Medicine
Last refreshed: 6 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04698005.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing