Last reviewed · How we verify
NCT06872255: VADYSMA
Per-oral Endoscopic Myotomy (POEM) in Patients with Postfundplication Dysphagia
NA trial testing Per Oral Endoscopic Myotomy (POEM) in Dysphagia in 30 participants. Not yet recruiting.
1 June 2027
Quick facts
| Lead sponsor | Institute for Clinical and Experimental Medicine |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 April 2025 |
| Primary completion | 1 June 2027 |
| Estimated completion | 1 June 2027 |
| Sites | 2 locations across Slovakia, Czechia |
Drugs / interventions tested
- Per Oral Endoscopic Myotomy (POEM)
Conditions studied
- Dysphagia — all drugs for Dysphagia →
- Dysphagia, Esophageal — all drugs for Dysphagia, Esophageal →
- Healthy — all drugs for Healthy →
Sponsor
Institute for Clinical and Experimental Medicine
Who can join
18 and older, any sex, with Dysphagia or Dysphagia, Esophageal. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Laparoscopic fundoplication represents the standard antireflux procedure, when conservative measures fail. However, any type of fundoplication may be accompanied by adverse events. Postfundoplication dysphagia (PFD) may hamper results of anti-reflux surgery. Endoscopic pneumatic dilation has been considered as the first line treatment option for persistent PFD. However, studies have not confirmed its effectiveness in this indication. Peroral endoscopic myotomy (POEM) became a standard treatment for the management of esophageal achalasia and moreover has also been assessed in a small cohort of patients with refractory PFD and some patients achieved significant treatment success. We plan to perform a prospective international cohort multicenter study assessing the efficacy of POEM in patients with persistent and severe PFD.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06872255
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Dysphagia
Currently open trials in the same condition.
- NCT07027826 — The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in · NA · recruiting
- NCT07264036 — Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study · NA · recruiting
- NCT07517926 — Chewing Gum and Cold Gargle on Post-Bronchoscopy Symptoms · NA · recruiting
- NCT07251140 — Dysphagia Study Using Novel Microphone Device · NA · recruiting
- NCT07076524 — MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL) · recruiting
Other Institute for Clinical and Experimental Medicine trials
Trials by the same sponsor.
- NCT07536087 — Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumor · NA · recruiting
- NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
- NCT07326826 — Hernia Repair Using Rectus Fascia Allograft · not yet recruiting
- NCT07153432 — Chronic Kidney Disease Screening · recruiting
- NCT06716541 — Biodegradable Stents in Liver Transplant RecipIents for Treatment of Biliary Anastomotic Strictures · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06872255 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Institute for Clinical and Experimental Medicine
- Last refreshed: 12 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06872255.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing