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NCT04682743
Prevention of Post-Operative Shivering
EARLY_PHASE1 trial testing paracetamol in Post-Operative Shivering in 120 participants. Completed in 22 February 2022.
16 January 2022
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 6 January 2021 |
| Primary completion | 16 January 2022 |
| Estimated completion | 22 February 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- paracetamol (Paracetamol) — full drug profile →
- ondansetron (ondansetron) — full drug profile →
- normal saline
Conditions studied
- Post-Operative Shivering — all drugs for Post-Operative Shivering →
Sponsor
Cairo University
Who can join
Adults 18 to 40, any sex, with Post-Operative Shivering. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Shivering and vasoconstriction are thermoregulatory mechanisms that are required to increase core body temperature (BT) in patients with core hypothermia. paracetamol is an antipyretic drug that has been in clinical use for a long time. It can lower the BT of febrile and nonfebrile patients. A previous study demonstrated that orally administered paracetamol can suppress in a dose-dependent manner the increase in the BT of patients with acute ischemic stroke. However, few studies have evaluated the effects of paracetamol on postoperative shivering.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04682743
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Other Cairo University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04682743 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 31 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04682743.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing