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NCT04661371
Necessity of Preoperative Empirical Antibiotic Use in Acute Cholecystitis
NA trial testing Laparoscopic cholecystectomy in Cholecystitis, Acute in 180 participants. Status unknown.
30 September 2021
Quick facts
| Lead sponsor | Seoul St. Mary's Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 180 |
| Start date | 2 March 2021 |
| Primary completion | 30 September 2021 |
| Estimated completion | 30 December 2021 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Laparoscopic cholecystectomy
Conditions studied
- Cholecystitis, Acute — all drugs for Cholecystitis, Acute →
Sponsor
Seoul St. Mary's Hospital
Who can join
Adults 19 to 70, any sex, with Cholecystitis, Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, the investigators compared the surgical outcomes according to the type of antibiotics before surgery in patients who did not have evidence of systemic infection during acute cholecystitis. The primary purpose of the study was to determine the type of preoperative antibiotics in patients who were scheduled for cholecystectomy, because of the mild (grade I) or moderate (grade 2) acute inflammatory gallbladder disease without gallbladder perforation. The investigators compared the incidence of postoperative complications according to the types of preoperative antibiotics(the first-generation vs second-generation cephalosporin). The secondary purpose of the study was to confirm the clinical efficacy of first-generation cephalosporins following the use of empirical antibiotics. And the investigators compare with postoperative pain, postoperative hospital stay, re-hospitalization, and need for additional treatment. In addition, the investigators compare the postoperative complications, such as atelectasis and postoperative ileus.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Preoperative antibiotic prophylaxis in acute cholecystectomy: a systematic review and meta-analysis of randomised controlled trials.
Singh A, Kaur M, Swaminathan C, Subramanian A, et al · · 2023 · cited 6× · PMID 38021359 · DOI 10.21037/tgh-23-48
Verify or expand the search:
- PubMed search for NCT04661371
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Laparoscopic cholecystectomy
Trials testing the same drug.
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- NCT07119203 — Surgical Techniques: Robotic Versus Conventional Laparoscopic Cholecystectomy IN Benign Gallbladder Disease · NA · recruiting
- NCT07161960 — Early Versus Delayed Cholecystectomy After Percutaneous Cholecystostomy in Moderate and Severe Cholecystitis (ESCAPE) · NA · recruiting
- NCT06459323 — the Outcomes of Laparoscopic Cholecystectomy for Acute Cholecystitis Within and Beyond the First 72 Hours, Does it Diffe · NA · not yet recruiting
- NCT06685250 — Postoperative Pain After a Laparoscopic Cholecystectomy · NA · not yet recruiting
Other recruiting trials for Cholecystitis, Acute
Currently open trials in the same condition.
- NCT06815822 — Prevention of Postoperative Hernias in Emergency Surgery · recruiting
- NCT06656299 — EOIB for Laparoscopic Cholecystectomy · NA · recruiting
- NCT06476054 — Optimal Timing for Laparoscopic Cholecystectomy After Cholecystostomy in Acute Cholecystitis Tokyo II/III Setting · NA · recruiting
- NCT05702775 — Endosonography-guided Gallbladder Drainage vs Non-endoscopic Treatment in Inoperable Acute Cholecystitis · NA · recruiting
Other Seoul St. Mary's Hospital trials
Trials by the same sponsor.
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- NCT07240844 — Enavogliflozin for the Management of Patients With Amyloid CardiomyopaThy · Phase 4 · not yet recruiting
- NCT06769087 — Comparing Immediate Removal and Postoperative 1 Day of Urinary Catheter After Colorectal Cancer Surgery · NA · enrolling by invitation
- NCT06442111 — The Role of Intravenous Ferritin in Optimizing Postoperative Recovery Following Pancreaticoduodenectomy · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04661371 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Seoul St. Mary's Hospital
- Last refreshed: 23 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04661371.
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