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NCT04660864
Nasal Cavity Cooling for the Symptomatic Relief of Migraine Headache - a Pilot Study
NA trial testing Nasal cavity cooling device. in Migraine in 15 participants. Completed in 23 December 2021.
23 December 2021
Quick facts
| Lead sponsor | Lund University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 15 |
| Start date | 3 March 2021 |
| Primary completion | 23 December 2021 |
| Estimated completion | 23 December 2021 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Nasal cavity cooling device.
Conditions studied
- Migraine — all drugs for Migraine →
Sponsor
Lund University
Who can join
Adults 18 to 70, any sex, with Migraine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to evaluate the effect of self-administered intranasal cooling for the symptomatic relief of migraine headache and associated symptoms in an "at home setting". 10-20 patients - who have been diagnosed according to the International Classification of Headache disorders (2nd Edition) criteria for Episodic migraine, with or without aura - will be included in the study. During a screening period of one month participants will record their migraine symptoms, any treatment and treatment effects. After a minimum om two migraine attacks the participants receive individual instructions on how to use the The RhinoChill® system. During the following treatment period of the study, participants are instructed to treat their upcoming three migraine attacks with 10 minutes of nasal cavity cooling according to the instructions and thereby register symptoms and treatment effects after 10 minutes, 1 hour, 2 hours, 24 hours and 48 hours.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Feasibility Trial on Intranasal Evaporative Cooling for Acute Migraine in an At-Home Setting.
Wolff M, Winnberg I, Tronvik E, Bakhsheshi MF, et al · · 2024 · PMID 39628733 · DOI 10.7759/cureus.72911
Verify or expand the search:
- PubMed search for NCT04660864
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04660864 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lund University
- Last refreshed: 24 January 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04660864.
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