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NCT04652921: CREGAAS
Creatine-Guanidinoacetic Acid Supplementation for Sarcopenia (CREGAAS)
NA trial testing Creatine-guanidinoacetic acid in Sarcopenia in 30 participants. Completed in 31 December 2021.
15 December 2021
Quick facts
| Lead sponsor | University of Novi Sad, Faculty of Sport and Physical Education |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 15 September 2020 |
| Primary completion | 15 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across Serbia |
Drugs / interventions tested
- Creatine-guanidinoacetic acid
- Inulin — full drug profile →
Conditions studied
- Sarcopenia — all drugs for Sarcopenia →
Sponsor
University of Novi Sad, Faculty of Sport and Physical Education
Who can join
Adults 65 to 90, any sex, with Sarcopenia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. Among potential therapeutic candidates, guanidinoacetate (GAA) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. Interestingly, GAA-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. Here, we plan to evaluate does creatine-GAA supplementation affects various biomarkers of sarcopenia in elderly.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04652921
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Novi Sad, Faculty of Sport and Physical Education trials
Trials by the same sponsor.
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- NCT06968715 — Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial · NA · completed
- NCT06788015 — Hydrogen-Infused Water for Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life · NA · completed
- NCT06660004 — Creatine HCl and Creatine Ethyl Ester Supplementation in Perimenopausal and Menopausal Women · NA · completed
- NCT06722326 — Hydrogen-rich Water and Appetite in Obesity · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04652921 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Novi Sad, Faculty of Sport and Physical Education
- Last refreshed: 1 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04652921.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing