Who is sponsoring NCT04639037?

NCT04639037 is sponsored by Assistance Publique - Hôpitaux de Paris.

What drugs are being tested in NCT04639037?

Interventions in NCT04639037: Automated adjustment of vasopressor, Manual adjustment of vasopressor.

What condition does NCT04639037 study?

NCT04639037 studies Hypotension.

Is NCT04639037 still recruiting?

NCT04639037 is currently completed. Last updated 3 May 2022.

Last reviewed 2022-05-03 · How we verify

NCT04639037: COMAP-ICU

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Control Mean Arterial Pressure in the Intensive Care Unit

Completed NA Last updated 3 May 2022

What this trial tests

NA trial testing Automated adjustment of vasopressor in Hypotension in 53 participants. Completed in 26 January 2022.

Timeline

8 January 2021

Primary endpoint
26 January 2022

26 January 2022

Quick facts

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	53
Start date	8 January 2021
Primary completion	26 January 2022
Estimated completion	26 January 2022
Sites	2 locations across France

Drugs / interventions tested

Automated adjustment of vasopressor
Manual adjustment of vasopressor

Conditions studied

Hypotension — all drugs for Hypotension →

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

Adults 18 to 99, any sex, with Hypotension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized controlled trial is to compare two different strategies of postoperative mean arterial pressure (MAP) management (manual versus automated) in patients who underwent a major surgery and admitted in the intensive care unit or post-anesthesia care unit for postoperative care. The investigators hypothesis is that the automated group will spend more time in a predetermined target MAP range of 80-90 mmHg compared to the manual group.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Tight control of mean arterial pressure using a closed loop system for norepinephrine infusion after high-risk abdominal surgery: a randomized controlled trial.
Coeckelenbergh S, Soucy-Proulx M, Van der Linden P, Clanet M, et al · · 2024 · cited 6× · PMID 38108944 · DOI 10.1007/s10877-023-01104-3

Verify or expand the search:

Other recruiting trials for Hypotension

Currently open trials in the same condition.

NCT07499947 — Predicting Spinal Hypotension in Cesarean Section · recruiting
NCT07494955 — "Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section" · NA · recruiting
NCT07481851 — Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients · recruiting
NCT06994494 — Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS · recruiting
NCT06953193 — Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia · NA · recruiting

Other Assistance Publique - Hôpitaux de Paris trials

Trials by the same sponsor.

NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04639037 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
Last refreshed: 3 May 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04639037.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing