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NCT04637087: PreMISe-AF
Precision Medicine in Ischemic Stroke and Atrial Fibrillation
NA trial testing Atrial fibrillation risk electronic health record alert in Atrial Fibrillation in 805 participants. Completed in 14 July 2024.
10 March 2022
Quick facts
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | screening |
| Enrollment | 805 |
| Start date | 11 March 2021 |
| Primary completion | 10 March 2022 |
| Estimated completion | 14 July 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Atrial fibrillation risk electronic health record alert
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Ischemic Stroke — all drugs for Ischemic Stroke →
Sponsor
Massachusetts General Hospital
Who can join
18 and older, any sex, with Atrial Fibrillation or Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall goal of this study is to minimize morbidity due to Atrial Fibrillation (AF). The specific objective is to develop and implement a rational and personalized approach to AF risk estimation that can inform management decisions with ischemic stroke. The investigators propose to develop a clinical AF risk estimation tool in the electronic health record and to test the effectiveness of implementing a clinical AF risk estimation tool into care for use by stroke neurologists during the care of acute ischemic stroke patients at Massachusetts General Hospital. The investigators will evaluate cardiac monitoring utilization calibrated to AF risk by stroke neurologists using a custom electronic health record (EHR) notification module. The investigators hypothesize that cardiac rhythm monitoring utilization will be positively correlated with the predicted risk of AF.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of a clinical atrial fibrillation risk estimation tool on cardiac rhythm monitor utilization following acute ischemic stroke: A prepost clinical trial.
Ashburner JM, Tack RWP, Khurshid S, Turner AC, et al · · 2025 · cited 1× · PMID 39978665 · DOI 10.1016/j.ahj.2025.02.010
Verify or expand the search:
- PubMed search for NCT04637087
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Massachusetts General Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04637087 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
- Last refreshed: 7 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04637087.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing