NCT04635254 is a NA clinical trial of Halophites-based cream 24 hours in Pain, Acute, sponsored by Aalborg University.

Who is sponsoring NCT04635254?

NCT04635254 is sponsored by Aalborg University.

What drugs are being tested in NCT04635254?

Interventions in NCT04635254: Halophites-based cream 24 hours, Halophites-based cream 48 hours, Vehicle cream 24 hours, Vehicle cream 48 hours, Histamine 1%, Cowhage.

What condition does NCT04635254 study?

NCT04635254 studies Pain, Acute, Itch.

Is NCT04635254 still recruiting?

NCT04635254 is currently completed. Last updated 19 January 2022.

Last reviewed 2022-01-19 · How we verify

NCT04635254

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Halophyte-based Cream on Pain and Itch

Completed NA Last updated 19 January 2022

What this trial tests

NA trial testing Halophites-based cream 24 hours in Pain, Acute in 32 participants. Completed in 1 December 2021.

Timeline

12 November 2020

Primary endpoint
1 November 2021

1 December 2021

Quick facts

Lead sponsor	Aalborg University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	basic science
Enrollment	32
Start date	12 November 2020
Primary completion	1 November 2021
Estimated completion	1 December 2021
Sites	1 location across Denmark

Drugs / interventions tested

Halophites-based cream 24 hours
Halophites-based cream 48 hours
Vehicle cream 24 hours
Vehicle cream 48 hours
Histamine 1%
Cowhage

Conditions studied

Pain, Acute — all drugs for Pain, Acute →
Itch — all drugs for Itch →

Sponsor

Aalborg University

Who can join

Adults 18 to 60, any sex, with Pain, Acute or Itch. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study the investigators wish to investigate whether halophyte-based cream applied to the skin can reduce itch applied by means of small needles from the plant mucuna pruriens (also called cowhage) or by histamine (an itch-evoking substance formed in the human body). Further, the investigators wishes to investigate whether long-term application of halophyte-based cream has a pain-relieving effect on heat/cold and pinprick stimulations.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of Salicornia-Based Skin Cream Application on Healthy Humans' Experimental Model of Pain and Itching.
Giordano R, Aliotta GE, Johannesen AS, Voetmann-Jensen D, et al · · 2022 · cited 8× · PMID 35215262 · DOI 10.3390/ph15020150
Clinical Measurement of Transepidermal Water Loss.
Kundu D, Jayaraman A, Sen CK. · · 2026 · cited 4× · PMID 40476522 · DOI 10.1089/wound.2024.0148

Verify or expand the search:

Other recruiting trials for Pain, Acute

Currently open trials in the same condition.

NCT07249827 — A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guid · Phase 2 · recruiting
NCT07053774 — Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain · Phase 2 · recruiting
NCT07009951 — Impact of Virtual Reality in Cardiac Electrophysiology · recruiting
NCT06960317 — Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements · NA · recruiting
NCT06754657 — CORA-Q15: Continuous vs. Single-injection Interscalene Block on QoR-15 in Outpatient Rotator Cuff Surgery · Phase 4 · recruiting

Other Aalborg University trials

Trials by the same sponsor.

NCT07580989 — Network Effects of Left M1 rTMS: A TMS-EEG Study · NA · recruiting
NCT07395882 — A New Model to Induce Itch and Inflammation · NA · not yet recruiting
NCT07395869 — Off-set Analgesia Induced by Cold Temperature · NA · not yet recruiting
NCT07266103 — Mechanistic Study of Personalized rTMS in Chronic Pain · NA · not yet recruiting
NCT07373392 — Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals Wi · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04635254 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aalborg University
Last refreshed: 19 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04635254.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing