NCT04630197

Using Online Delivered Therapy and Brain Imaging to Better Understand OCD

Completed NA Last updated 27 December 2023

What this trial tests

NA trial testing e-CBT in Obsessive-Compulsive Disorder in 10 participants. Completed in 28 July 2022.

Timeline

1 January 2021

Primary endpoint
1 June 2022

28 July 2022

Quick facts

Lead sponsor	Callum Stephenson
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	10
Start date	1 January 2021
Primary completion	1 June 2022
Estimated completion	28 July 2022
Sites	1 location across Canada

Drugs / interventions tested

• e-CBT

Conditions studied

• Obsessive-Compulsive Disorder — all drugs for Obsessive-Compulsive Disorder →

Sponsor

Callum Stephenson

Who can join

Adults 18 to 65, any sex, with Obsessive-Compulsive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will implement an e-CBT program for OCD and observe its effects on brain activation levels using functional magnetic resonance imaging (fMRI). It is hypothesized that brain activation levels in the basal ganglia and frontal cortex will decrease following treatment. Individuals with OCD will be offered a 16-week e-CBT program with ERP mirroring in-person CBT content that will be administered through a secure online platform. Efficacy of treatment will be evaluated using clinically validated symptomology questionnaires at baseline, week 8, week 16, and at a 6-month follow-up. Using fMRI at baseline and post-treatment, brain activation levels will be assessed at resting state, and while exposed to anxiety-inducing images (i.e., dirty dishes if cleanliness is an obsession). The effects of treatment on brain activation levels and the correlation between symptom changes and activation levels will be analyzed.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Using electronically delivered therapy and brain imaging to understand OCD pathology: A pilot feasibility study.
   Stephenson C, Malakouti N, Nashed JY, Salomons T, et al · · 2023 · cited 3× · PMID 36970278 · DOI 10.3389/fpsyt.2023.1050530
2. Using Electronically Delivered Therapy and Brain Imaging to Understand Obsessive-Compulsive Disorder Pathophysiology: Protocol for a Pilot Study.
   Stephenson C, Malakouti N, Nashed JY, Salomons T, et al · · 2021 · cited 3× · PMID 34348889 · DOI 10.2196/30726