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NCT04629599: HeAL
IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)
NA trial testing Interpersonal psychotherapy for major depression following perinatal loss in Major Depressive Disorder in 200 participants. Currently enrolling.
1 November 2025
Quick facts
| Lead sponsor | Michigan State University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 1 August 2021 |
| Primary completion | 1 November 2025 |
| Estimated completion | 1 November 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Interpersonal psychotherapy for major depression following perinatal loss
- Coping with Depression
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
Sponsor
Michigan State University
Who can join
Adults 18 to 50, female only, with Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan. The trial will be the first fully powered randomized trial of treatment for any psychiatric disorder following perinatal loss.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Protocol for the Healing After Loss (HeAL) Study: a randomised controlled trial of interpersonal psychotherapy (IPT) for major depression following perinatal loss.
Johnson JE, Price AB, Sikorskii A, Key KD, et al · · 2022 · PMID 35440458 · DOI 10.1136/bmjopen-2021-057747
Verify or expand the search:
- PubMed search for NCT04629599
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Michigan State University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04629599 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Michigan State University
- Last refreshed: 1 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04629599.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing