Last reviewed · How we verify
NCT04628078
LAAC-registry: Clinical Outcome After Echocardiography-guided LAA-closure
trial testing Use of echocardiography guidance for LAAC in Atrial Fibrillation in 1,000 participants. Currently enrolling.
1 June 2023
Quick facts
| Lead sponsor | Insel Gruppe AG, University Hospital Bern |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 12 August 2015 |
| Primary completion | 1 June 2023 |
| Estimated completion | 1 June 2027 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Use of echocardiography guidance for LAAC
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
- Thromboembolism — all drugs for Thromboembolism →
Sponsor
Insel Gruppe AG, University Hospital Bern
Who can join
18 and older, any sex, with Atrial Fibrillation or Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study aims at comparing, in a large cohort of consecutive clinically indicated left atrial appendage closure, clinical and imaging outcomes between different subpopulations.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Pericardial Effusion After Left Atrial Appendage Closure: Timing, Predictors, and Clinical Impact.
Galea R, Bini T, Krsnik JP, Touray M, et al · · 2024 · cited 13× · PMID 38795087 · DOI 10.1016/j.jcin.2024.01.310 -
Percutaneous left atrial appendage closure with concomitant dual-device implantation: a single-center observational study.
Gasys A, Galea R, Bini T, Perich-Krsnik J, et al · · 2025 · PMID 41503611 · DOI 10.3389/fcvm.2025.1692521 -
Feasibility and Impact of Left Atrial Appendage Closure in Patients with Cardiac Implantable Electronic Devices: Insights from a Prospective Registry.
Bini T, Ledwoch S, Galea R, Gasys A, et al · · 2025 · PMID 40507616 · DOI 10.3390/jcm14113857
Verify or expand the search:
- PubMed search for NCT04628078
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atrial Fibrillation
Currently open trials in the same condition.
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- NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
- NCT07428967 — AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function · NA · recruiting
- NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting
Other Insel Gruppe AG, University Hospital Bern trials
Trials by the same sponsor.
- NCT06546384 — GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease · NA · not yet recruiting
- NCT07524049 — Giving Children a Voice in Paediatric Anaesthesia · not yet recruiting
- NCT07415668 — Motor Eloquent Navigated Transcranial Magnetic Stimulation for Radiosurgery Planning · NA · not yet recruiting
- NCT07478536 — Stockholm3 Test Validation in Men on Active Surveillance in Switzerland (CHAS3 Trial) · not yet recruiting
- NCT07201506 — Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04628078 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Insel Gruppe AG, University Hospital Bern
- Last refreshed: 22 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04628078.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing