Last reviewed · How we verify
NCT04627987: MASTER
Mechanisms of Excess Risk in Aortic Stenosis
trial testing Cardiac MRI scan in Aortic Stenosis in 192 participants. Status unknown.
1 December 2025
Quick facts
| Lead sponsor | University College, London |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 192 |
| Start date | 23 March 2021 |
| Primary completion | 1 December 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Cardiac MRI scan
- Serum biomarkers (High sensitivity troponin, NT-proBNP
- Implantable Loop Recorder
- 6 minute walk test
- Echocardiogram
Conditions studied
- Aortic Stenosis — all drugs for Aortic Stenosis →
- Non-Sustained VT — all drugs for Non-Sustained VT →
- Heart Failure — all drugs for Heart Failure →
Sponsor
University College, London
Who can join
18 and older, any sex, with Aortic Stenosis or Non-Sustained VT. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Aortic stenosis (AS) is caused by narrowing of one of the main heart valves. Replacing the valve is the only treatment to prevent the heart from failing or death. The timing of replacement is currently often too late - half of patients are left with permanent scarring and a quarter die within 3.5 years. Studies are underway to see if earlier replacement makes a difference. But for those with scarring of the heart, there is currently no tailored treatment. I want to change this by understanding why and how patients with scar are dying and what the investigators can do to prevent this. In this study, the investigators will use a heart scan (MRI) to detect scarring before valve replacement. After replacement, patients will receive a tiny monitor (paper clip size), which the investigators inject underneath the skin. This monitor continuously checks the heartbeat and can detect increased body fluid due to heart failure. The investigators will monitor patients for an average of 3 years to see if scarring is linked to abnormal heart rhythms and heart failure. Once the investigators know how and why, the investigators can target patients with available medications and design studies using specialised treatments, eg defibrillator implantation, to protect patients with scar from dying.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement.
Bennett J, Thornton GD, Nitsche C, Gama FF, et al · · 2024 · cited 5× · PMID 39629586 · DOI 10.1161/circimaging.124.017425 -
Heart failure and excess mortality after aortic valve replacement in aortic stenosis.
Aziminia N, Nitsche C, Mravljak R, Bennett J, et al · · 2023 · cited 3× · PMID 36877090 · DOI 10.1080/14779072.2023.2186853
Verify or expand the search:
- PubMed search for NCT04627987
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT03586518 — Validating Novel, Non-contrast Cardiac MRI Imaging in Haemodialysis Patients · recruiting
Other recruiting trials for Aortic Stenosis
Currently open trials in the same condition.
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- NCT07205068 — Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and P · NA · recruiting
- NCT07052071 — Impact of Transcatheter Aortic Valve Implantation (TAVI) on the Gut Microbiota in Patients With Aortic Valve Stenosis · recruiting
- NCT07144189 — AI Assessment of Low-Gradient Aortic Stenosis Severity Based on Echocardiography · recruiting
Other University College, London trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04627987 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College, London
- Last refreshed: 30 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04627987.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing