Last reviewed · How we verify
NCT04609618
Evaluatation of Appscent Device Safety and Effectiveness for Relief of Obstructive Sleep Apnea (OSA) Syndrome in Adults.
EARLY_PHASE1 trial testing Appscent Device in Obstructive Sleep Apnea in 23 participants. Completed in 26 August 2021.
26 August 2021
Quick facts
| Lead sponsor | Y.A. Appscent Ltd. |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 23 |
| Start date | 15 October 2020 |
| Primary completion | 26 August 2021 |
| Estimated completion | 26 August 2021 |
| Sites | 1 location across Israel |
Drugs / interventions tested
- Appscent Device
Conditions studied
- Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
Sponsor
Y.A. Appscent Ltd.
Who can join
Adults 40 to 70, any sex, with Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obstructive Sleep Apnea (OSA) syndrome is a disorder characterized by repetitive episodes of upper airway obstruction that occur during sleep. The standard treatment for apnea remains a device consisting of a pump and nasal mask that provide continuous positive airway pressure (CPAP). The major disadvantage of CPAP is the relatively low compliance. Appscent developed a non-contact effortless bedside solution based on the following: odors modify respiratory patterns during wake . Mildly trigeminal and pure olfactory odorants do not arouse or wake.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Respiration-triggered olfactory stimulation reduces obstructive sleep apnea severity: A prospective pilot study.
Perl O, Kemer L, Green A, Arish N, et al · · 2024 · cited 2× · PMID 38740050 · DOI 10.1111/jsr.14236
Verify or expand the search:
- PubMed search for NCT04609618
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04609618 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Y.A. Appscent Ltd.
- Last refreshed: 4 January 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04609618.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing