NCT04588558 is a NA clinical trial of Flywheel exercise in Osteoarthritis Knees Both, sponsored by Istanbul Medipol University Hospital.

Who is sponsoring NCT04588558?

NCT04588558 is sponsored by Istanbul Medipol University Hospital.

What drugs are being tested in NCT04588558?

Interventions in NCT04588558: Flywheel exercise, Home exercise, Electrotherapy group.

What condition does NCT04588558 study?

NCT04588558 studies Osteoarthritis Knees Both, Pain, Chronic, Walking, Difficulty.

Is NCT04588558 still recruiting?

NCT04588558 is currently completed. Last updated 12 April 2021.

Last reviewed 2021-04-12 · How we verify

NCT04588558

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Investigation of the Effectiveness of a Structured Squat-based Program in Knee Osteoarthritis Rehabilitation

Completed NA Last updated 12 April 2021

What this trial tests

NA trial testing Flywheel exercise in Osteoarthritis Knees Both in 75 participants. Completed in 2 April 2021.

Timeline

15 September 2020

Primary endpoint
5 February 2021

2 April 2021

Quick facts

Lead sponsor	Istanbul Medipol University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	75
Start date	15 September 2020
Primary completion	5 February 2021
Estimated completion	2 April 2021
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Flywheel exercise
Home exercise
Electrotherapy group

Conditions studied

Osteoarthritis Knees Both — all drugs for Osteoarthritis Knees Both →
Pain, Chronic — all drugs for Pain, Chronic →
Walking, Difficulty — all drugs for Walking, Difficulty →

Sponsor

Istanbul Medipol University Hospital

Who can join

Adults 45 to 65, any sex, with Osteoarthritis Knees Both or Pain, Chronic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main purpose of the study is to examine the effect of squat-based exercise approach in individuals with knee osteoarthritis. The aim of this study is to compare effect to three groups (flywheel exercise group, electrotherapy modality group and home exercise group) and also decrease the pain, increase muscle strength, activation values and increase the functional level of individuals. Osteoarthritis is the most common rheumatological disease in the world that primarily results in progressive cartilage destruction. Changes occurring as a result of osteoarthritis are the main cause of disability and are most common in the knee joint. Osteoarthritis; problems such as pain, tenderness, joint stiffness, joint swelling, movement restriction, joint deformities, loss of muscle strength, decreased functional capacity and impaired quality of life are observed. The daily life activities of individuals with knee osteoarthritis are restricted by the problems of walking up and down stairs, getting out of the chair, standing, squatting, walking. Improving the symptoms of the disease is an important goal of the rehabilitation process of patients with knee osteoarthritis. In individuals with knee osteoarthritis, joint structure and deformation in cartilage also show loss of strength with muscles. Strengthening exercises have been used in patients with knee osteoarthritis for a long time. Squat exercise is a type of exercise that is widely used as a strengthening exercise.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Exercise for osteoarthritis of the knee.
Lawford BJ, Hall M, Hinman RS, Van der Esch M, et al · · 2024 · cited 37× · PMID 39625083 · DOI 10.1002/14651858.cd004376.pub4

Verify or expand the search:

Other recruiting trials for Osteoarthritis Knees Both

Currently open trials in the same condition.

NCT06082531 — Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis · NA · recruiting
NCT04814082 — Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Ar · NA · recruiting

Other Istanbul Medipol University Hospital trials

Trials by the same sponsor.

NCT07508371 — Menthol Massage for Post-Bypass Pain & Anxiety · NA · not yet recruiting
NCT07575477 — Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery · NA · not yet recruiting
NCT07525115 — Effects of Proprioceptive Neuromuscular Facilitation-Based Lower Extremity Training on Balance, Gait, and Functional Ind · NA · not yet recruiting
NCT07467278 — Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome · NA · not yet recruiting
NCT07468864 — Validity of the Turkish Situational Vertigo Questionnaire · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04588558 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istanbul Medipol University Hospital
Last refreshed: 12 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04588558.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing