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NCT04580680: GlobalARRT
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
trial testing Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT) in Critical Illness in 1,000 participants. Currently enrolling.
30 September 2025
Quick facts
| Lead sponsor | Careggi Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 1 November 2020 |
| Primary completion | 30 September 2025 |
| Estimated completion | 30 September 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
Conditions studied
- Critical Illness — all drugs for Critical Illness →
- Acute Kidney Injury — all drugs for Acute Kidney Injury →
- Sepsis — all drugs for Sepsis →
- Systemic Inflammatory Response Syndrome — all drugs for Systemic Inflammatory Response Syndrome →
Sponsor
Careggi Hospital
Who can join
Eligibility, any sex, with Critical Illness or Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings. The efficacy of most of these treatments on removal of inflammatory mediators is the main rationale behind the use of EBP in critically ill patients with multiorgan dysfunction. Nonetheless, there are still some doubts as to the clinical efficacy of bacterial toxins and cytokines removal and many clinical trials aiming at exploring the effect of EBP on long-term outcomes of septic patients have failed to demonstrate consistent results regarding 28 day- or hospital-mortality rates. The primary aim of this observational prospective web-based registry is to define the possible clusters of critically ill patients - treated with extracorporeal blood purification therapies worldwide - who are homogeneous regarding both clinical and treatment characteristics and seem to benefit the most from EBP.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Rationale for sequential extracorporeal therapy (SET) in sepsis.
Ronco C, Chawla L, Husain-Syed F, Kellum JA. · · 2023 · cited 47× · PMID 36750878 · DOI 10.1186/s13054-023-04310-2 -
Survival benefit of resin cartridge extracorporeal blood purification therapy in patients with septic shock.
Efe S, Hanci P, Inal V. · · 2024 · cited 2× · PMID 38812634 · DOI 10.55730/1300-0144.5773
Verify or expand the search:
- PubMed search for NCT04580680
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
Trials testing the same drug.
- NCT04033224 — Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure · recruiting
Other recruiting trials for Critical Illness
Currently open trials in the same condition.
- NCT06189924 — Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients · recruiting
- NCT07418242 — Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients · recruiting
- NCT07101640 — PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysp · Phase 1, PHASE2 · recruiting
- NCT07177183 — Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure · NA · recruiting
- NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting
Other Careggi Hospital trials
Trials by the same sponsor.
- NCT04033224 — Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure · recruiting
- NCT03807414 — Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients · active not recruiting
- NCT04341974 — Perioperative Use of Serum Creatinine and Postoperative Acute Kidney Injury · completed
- NCT03820232 — Intraoperative Body Core Temperature Monitoring: Oesophageal Probe vs Heated Controlled Servo Sensor · completed
- NCT03796338 — Sleep Quantity and Quality in the ICU: a Prospective Observational Stud · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04580680 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Careggi Hospital
- Last refreshed: 12 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04580680.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing