NCT04569656 (PHGG-PD) is a Phase 2 clinical trial of hydrolyzed guar gum in Parkinson Disease, sponsored by IRCCS San Raffaele Roma.

Who is sponsoring NCT04569656?

NCT04569656 is sponsored by IRCCS San Raffaele Roma.

What drugs are being tested in NCT04569656?

Interventions in NCT04569656: hydrolyzed guar gum.

What condition does NCT04569656 study?

NCT04569656 studies Parkinson Disease.

Is NCT04569656 still recruiting?

NCT04569656 is currently completed. Last updated 10 April 2024.

Last reviewed 2024-04-10 · How we verify

NCT04569656: PHGG-PD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Chronic Constipation in Parkinson's Disease

Completed Phase 2 Last updated 10 April 2024

What this trial tests

Phase 2 trial testing hydrolyzed guar gum in Parkinson Disease in 34 participants. Completed in 20 December 2016.

Timeline

2 February 2016

Primary endpoint
20 December 2016

20 December 2016

Quick facts

Lead sponsor	IRCCS San Raffaele Roma
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	34
Start date	2 February 2016
Primary completion	20 December 2016
Estimated completion	20 December 2016
Sites	1 location across Italy

Drugs / interventions tested

hydrolyzed guar gum — full drug profile →

Conditions studied

Parkinson Disease — all drugs for Parkinson Disease →

Sponsor

IRCCS San Raffaele Roma — full company profile →

Who can join

18 and older, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic constipation is the most common gastrointestinal symptom reported by PD patients; it could be one of the manifestations of disease onset. PHGG fiber is extracted from a herbaceous plant (Cyamopsis Tetra-Gonolobus, family: Leguminosae) of Indian origin: it produces 5/9 pods containing seeds which produce the famous guar gum, that is a natural polysaccharide.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection.
Shoaib S, Ansari MA, Fatease AA, Safhi AY, et al · · 2023 · cited 37× · PMID 36986610 · DOI 10.3390/pharmaceutics15030749
Effectiveness of an herbaceous derivatives, PHGG, plus sodium hyaluronate in the treatment of chronic constipation in patients with Parkinson's disease: a pilot study.
Vacca L, Proietti S, Bravi D, Radicati FG, et al · · 2022 · cited 3× · PMID 34086122 · DOI 10.1007/s10072-021-05342-8

Verify or expand the search:

Other recruiting trials for Parkinson Disease

Currently open trials in the same condition.

NCT07399496 — Accelerated TMS for Apathy in PD · NA · recruiting
NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
NCT07442370 — The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients · NA · recruiting
NCT06848205 — Percept Transitions in FOG and PD · NA · recruiting
NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting

Other IRCCS San Raffaele Roma trials

Trials by the same sponsor.

NCT07431671 — Feeding Disorders in Children · NA · recruiting
NCT07097103 — Parkinson's Research In Metagenomic Early Stage Biomarkers · NA · not yet recruiting
NCT06868953 — Use of the Combination of Sumatriptan and Naproxen in the Acute Treatment of Migraine: Real World Evidence Study · not yet recruiting
NCT06839482 — Robotic Rehabilitation of the Upper Limb in Subacute Stroke · NA · recruiting
NCT06915584 — Drug Management in Heart Failure · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04569656 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by IRCCS San Raffaele Roma
Last refreshed: 10 April 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04569656.

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