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NCT04569604: MR-hypoPT
QoL and Cognitive Function in Patients With Hypoparathyroidism
trial testing MRI scans in Hypoparathyroidism in 64 participants. Completed in 1 December 2021.
1 October 2020
Quick facts
| Lead sponsor | University of Aarhus |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 64 |
| Start date | 1 October 2019 |
| Primary completion | 1 October 2020 |
| Estimated completion | 1 December 2021 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- MRI scans
- Neuro cognitive tests
- Questionnaires on Quality of Life
- Blood samples — full drug profile →
- 24 hr urine samples
Conditions studied
- Hypoparathyroidism — all drugs for Hypoparathyroidism →
- Pseudo Hypoparathyroidism — all drugs for Pseudo Hypoparathyroidism →
Sponsor
University of Aarhus
Who can join
Adults 18 to 70, any sex, with Hypoparathyroidism or Pseudo Hypoparathyroidism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hypoparathyroidism (HypoPT) is a disease with inadequate production of parathyroid hormone (PTH) from the parathyroid glands leading to hypocalcemia. The most common form is postsurgical HypoPT due to neck surgery resulting in removed or damaged parathyroid glands. HypoPT is a complex disease with a reduced Quality of life, mild cognitive impairment and in some patients have brain calcifications. The aim of the present study is to investigate the cognitive function in patients with postsurgical and non-surgical (HypoPT) by neuropsychological assessments and magnetic resonance imaging (MRI). The investigators will apply a contrast-enhanced MRI based method to HypoPT patients and age- and gender matched controls to examine whether capillary dysfunction can be detected, and whether symptom severity across patients correlates with the degree of capillary dysfunction in certain brain regions. To our knowledge there have been no previous studies on cognitive impairment and its origin in patients with HypoPT. The investigators hypothesize that the symptoms of HypoPT patients represent various degrees of capillary dysfunction, which interfere with their brain function.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04569604
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Hypoparathyroidism
Currently open trials in the same condition.
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- NCT07197450 — Efficacy and Safety of XH02 for the Treatment of Hypoparathyroidism · EARLY_PHASE1 · recruiting
- NCT06645899 — Institution of an Italian Multicenter Database of Patients Affected by Hypoparathyroidism or Pseudohypoparathyroidism · recruiting
Other University of Aarhus trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04569604 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Aarhus
- Last refreshed: 23 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04569604.
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