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NCT04568681
Deep Brain Stimulation Effects in Dystonia
trial testing Deep brain stimulation (DBS) in Dystonia in 7 participants. Completed in 12 July 2022.
12 July 2022
Quick facts
| Lead sponsor | University of Florida |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 7 |
| Start date | 5 November 2020 |
| Primary completion | 12 July 2022 |
| Estimated completion | 12 July 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Deep brain stimulation (DBS)
Conditions studied
- Dystonia — all drugs for Dystonia →
Sponsor
University of Florida
Who can join
18 and older, any sex, with Dystonia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Deep Brain Stimulation (DBS) is an effective therapy for patients with medically refractory primary dystonia. However, DBS programming for dystonia is not standardized and multiple clinic visits are frequently required to adequately control symptoms. We aim to longitudinally record brain signals from patients using a novel neurostimulator that can record brain signals. We will correlate brain signals to clinical severity scores to identify pathological rhythms in the absence of DBS, and we will study the effects of DBS on these signals in order to guide clinical programming. We are going to recruit patients who receive the Medtronic Percept device, which allows for brain signal recordings (this feature is FDA approved). The investigators will be conducting an observational study using this device to collect data that the subjects receive as standard of care.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.
Rissardo JP, Vora NM, Tariq I, Mujtaba A, et al · · 2023 · cited 17× · PMID 38004040 · DOI 10.3390/medicina59111991
Verify or expand the search:
- PubMed search for NCT04568681
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Deep brain stimulation (DBS)
Trials testing the same drug.
- NCT06360991 — DBS for Treatment-resistant Obsessive-compulsive Disorder · NA · not yet recruiting
- NCT03605316 — Deep Electrical Neuromodulation in Obsessive-compulsive Disorder · completed
Other recruiting trials for Dystonia
Currently open trials in the same condition.
- NCT07417280 — LIFUS For Neurological Disorders · NA · recruiting
- NCT06554288 — Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy · Phase 1 · recruiting
- NCT07190092 — Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment. · NA · recruiting
- NCT07244549 — Chronic Outcome Monitoring for DBS in Dystonia · recruiting
- NCT06585618 — A Multicenter Pediatric Deep Brain Stimulation Registry · recruiting
Other University of Florida trials
Trials by the same sponsor.
- NCT03429413 — Maximizing HPV Vaccination: Real-time Reminders, Guidance, and Recommendations - Part 4: Feasibility Trial · NA · not yet recruiting
- NCT06127550 — taVNS for Letter Learning in Dyslexia · NA · suspended
- NCT07507214 — Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athl · Phase 2, PHASE3 · not yet recruiting
- NCT07492316 — RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) · Phase 1 · not yet recruiting
- NCT06670794 — Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Dri · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04568681 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Florida
- Last refreshed: 15 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04568681.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing