NCT04566081

Digital Interventions in Neurorehabilitation: iTALKbetter

Completed NA Results posted Last updated 10 March 2026

What this trial tests

NA trial testing iTalkBetter Trained Items in Stroke in 31 participants. Completed in 25 February 2022.

Timeline

7 September 2020

Primary endpoint
25 February 2022

25 February 2022

Quick facts

Lead sponsor	University College, London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	31
Start date	7 September 2020
Primary completion	25 February 2022
Estimated completion	25 February 2022
Sites	1 location across United Kingdom

Drugs / interventions tested

• iTalkBetter Trained Items
• iTalkBetter Untrained Items

Conditions studied

• Stroke — all drugs for Stroke →
• Aphasia — all drugs for Aphasia →
• Anomia — all drugs for Anomia →

Sponsor

University College, London

Who can join

Eligibility, any sex, with Stroke or Aphasia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Accuracy Performance (%) on a Bespoke Word Retrieval Test: WRT. Two Conditions: 1. Trained Items 2. Untrained Items Primary · Two time points: 1. Pre- intervention (T3 = 6 weeks post baseline) 2. Post-intervention (T4 = 12 weeks post baseline)

The WRT is custom test of word retrieval comprised of a subset of the trained and untrained items form the iTALKbetter therapy. Participants accuracy on the word retrieval test is measured at two timepoints: pre intervention (T3), and post intervention (T4). There are 110 trained and 110 untrained items. Accuracy is reported as a percentage score (min = 0%, max = 100%) for each of the four conditions. The outcome is the percentage change in performance on the WRT. To investigate the efficacy of iTalkBetter in improving the retrieval of trained single words on the WRT, a repeated measures ANO

Trained items (T3)

Group	Value	95% CI
iTALKbetter	38.3	± 0.85

Untrained items (T3)

Group	Value	95% CI
iTALKbetter	38.4	± 0.95

Trained items (T4)

Group	Value	95% CI
iTALKbetter	50.6	± 1.8

Untrained items (T4)

Group	Value	95% CI
iTALKbetter	43	± 1.95

Sponsor's own description

iTALKBetter will provide an app-based therapy for people with word retrieval difficulties who have had a stroke.

This study aims to test the therapy application for people with naming difficulties through a small scale item-randomized controlled trial.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Efficacy of a gamified digital therapy for speech production in people with chronic aphasia (iTalkBetter): behavioural and imaging outcomes of a phase II item-randomised clinical trial.
   Upton E, Doogan C, Fleming V, Leyton PQ, et al · · 2024 · cited 7× · PMID 38685927 · DOI 10.1016/j.eclinm.2024.102483