Who is sponsoring NCT04556890?

NCT04556890 is sponsored by University of California, Los Angeles.

What drugs are being tested in NCT04556890?

Interventions in NCT04556890: Active rTMS/Active iTBS DFPLC/Sham Pain M1, Active rTMS/Active iTBS.

What condition does NCT04556890 study?

NCT04556890 studies Major Depressive Disorder, Chronic Pain.

Is NCT04556890 still recruiting?

NCT04556890 is currently recruiting now. Last updated 19 September 2025.

Last reviewed 2025-09-19 · How we verify

NCT04556890

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pain and Major Depressive Disorder

Recruiting now NA Last updated 19 September 2025

What this trial tests

NA trial testing Active rTMS/Active iTBS DFPLC/Sham Pain M1 in Major Depressive Disorder in 54 participants. Currently enrolling.

Timeline

1 March 2023

Primary endpoint
30 June 2027

31 October 2027

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	54
Start date	1 March 2023
Primary completion	30 June 2027
Estimated completion	31 October 2027
Sites	1 location across United States

Drugs / interventions tested

Active rTMS/Active iTBS DFPLC/Sham Pain M1
Active rTMS/Active iTBS

Conditions studied

Major Depressive Disorder — all drugs for Major Depressive Disorder →
Chronic Pain — all drugs for Chronic Pain →

Sponsor

University of California, Los Angeles

Who can join

Adults 18 to 75, any sex, with Major Depressive Disorder or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 treatments of blinded transcranial magnetic stimulation. There is no control group as all subjects will receive some form of active treatment. Subjects are required to participate in 30-33 study visits and volunteer 40 hours of their time. Compensation for this study is $150 for completing all study activities.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Can we use the tools we already have to help patients in need? Evaluating practice-based evidence of analgesic effects from intermittent theta burst stimulation for treatment of depression.
Slepian PM. · · 2024 · PMID 38505213 · DOI 10.1080/24740527.2024.2310806

Verify or expand the search:

Other recruiting trials for Major Depressive Disorder

Currently open trials in the same condition.

NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
NCT06705478 — Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disor · Phase 2 · recruiting
NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
NCT07316803 — Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness · NA · recruiting
NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting

Other University of California, Los Angeles trials

Trials by the same sponsor.

NCT04846517 — rTMS for Aneroxia Nervosa in Youth · NA · not yet recruiting
NCT06701760 — Sodium Lactate in Severe TBI · Phase 2 · not yet recruiting
NCT04996667 — Effect of iNO in Patients With Submassive and Massive PE · Phase 2 · withdrawn
NCT05067387 — Evaluation of Oral THC and CBD in Men and Women · Phase 1 · not yet recruiting
NCT07534696 — Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04556890 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
Last refreshed: 19 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04556890.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing