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NCT04527874: VITAL
Viral Load Triggered ART Care in Lesotho
NA trial testing VITAL model in HIV Infections in 5,809 participants. Completed in 7 August 2024.
7 August 2024
Quick facts
| Lead sponsor | Swiss Tropical & Public Health Institute |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 5,809 |
| Start date | 14 October 2020 |
| Primary completion | 7 August 2024 |
| Estimated completion | 7 August 2024 |
| Sites | 18 locations across Lesotho |
Drugs / interventions tested
- VITAL model
Conditions studied
- HIV Infections — all drugs for HIV Infections →
Sponsor
Swiss Tropical & Public Health Institute
Who can join
18 and older, any sex, with HIV Infections. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This cluster randomized clinical trial at 18 nurse-led rural health centers in Lesotho will test an automated differentiated service delivery model using viral load results, other clinical characteristics and participants' preference to automatically triage participants into groups requiring different levels of attention and care.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Assessment of a viral load result-triggered automated differentiated service delivery model for people taking ART in Lesotho (the VITAL study): Study protocol of a cluster-randomized trial.
Tschumi N, Lerotholi M, Kopo M, Kao M, et al · · 2022 · cited 8× · PMID 35511950 · DOI 10.1371/journal.pone.0268100 -
Cervical cancer screening delay and associated factors among women with HIV in Lesotho: a mixed-methods study.
Harder MT, Mokete M, Chammartin F, Lerotholi M, et al · · 2024 · cited 6× · PMID 39354488 · DOI 10.1186/s12905-024-03382-8 -
eHealth supported multi-months dispensing of antiretroviral therapy: a mixed-methods preference assessment in rural Lesotho.
Scherrer R, Tschumi N, Lejone TI, Kopo M, et al · · 2022 · cited 6× · PMID 35277206 · DOI 10.1186/s40814-022-01019-x -
Integrating clinical decision support and mobile health for differentiated HIV service delivery in Lesotho (VITAL): a cluster-randomised non-inferiority trial.
Tschumi N, Lerotholi M, Kopo M, Kao M, et al · · 2026 · PMID 42005925 · DOI 10.1016/j.eclinm.2026.103850 -
Integrating clinical decision support and mobile health for differentiated HIV service delivery in Lesotho (VITAL): a cluster-randomised non-inferiority trial
Tschumi N, Lerotholi M, Kopo M, Kao M, et al · · 2026 -
Technical feasibility and uptake of tailored mobile health support for people with HIV in Lesotho
Lerotholi MD, Kopo M, Kao M, Motaboli L, et al · · 2025 · DOI 10.21203/rs.3.rs-8214790/v1
Verify or expand the search:
- PubMed search for NCT04527874
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Swiss Tropical & Public Health Institute trials
Trials by the same sponsor.
- NCT06606860 — Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets · Phase 1 · completed
- NCT06373835 — Efficacy and Safety of Emodepside in Adults Infected With Strongyloidiasis Stercoralis · Phase 2 · completed
- NCT06304831 — Use of Facility Ratings to Improve Satisfaction With Heath Care for Children · NA · completed
- NCT05644067 — Assessment of the Malaria Vaccine Candidate SumayaVac-1 in Healthy Adults Aged 18-45 Years Living in a Malaria Endemic C · Phase 1 · completed
- NCT06648603 — Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04527874 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Swiss Tropical & Public Health Institute
- Last refreshed: 1 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04527874.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing