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NCT04502225
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure
NA trial testing Tilt in Supine Hypertension in 44 participants. Currently enrolling.
31 August 2026
Quick facts
| Lead sponsor | Vanderbilt University Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 21 August 2020 |
| Primary completion | 31 August 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Tilt
- Elevated trunk
- Tilt - In home
- Elevated Trunk - In home
Conditions studied
- Supine Hypertension — all drugs for Supine Hypertension →
- Autonomic Failure — all drugs for Autonomic Failure →
Sponsor
Vanderbilt University Medical Center
Who can join
Adults 18 to 85, any sex, with Supine Hypertension or Autonomic Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04502225
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Supine Hypertension
Currently open trials in the same condition.
- NCT05489575 — CPAP for the Treatment of Supine Hypertension · NA · recruiting
- NCT03312556 — Treatment of Supine Hypertension in Autonomic Failure (CPAP) · NA · recruiting
Other Vanderbilt University Medical Center trials
Trials by the same sponsor.
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- NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04502225 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
- Last refreshed: 6 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04502225.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing