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NCT03312556
Treatment of Supine Hypertension in Autonomic Failure (CPAP)
NA trial testing continuous positive airway pressure (CPAP) in Supine Hypertension in 12 participants. Currently enrolling.
21 September 2026
Quick facts
| Lead sponsor | Vanderbilt University Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 12 |
| Start date | 21 September 2017 |
| Primary completion | 21 September 2026 |
| Estimated completion | 21 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- continuous positive airway pressure (CPAP)
- Placebo
Conditions studied
- Supine Hypertension — all drugs for Supine Hypertension →
- Autonomic Failure — all drugs for Autonomic Failure →
Sponsor
Vanderbilt University Medical Center
Who can join
Adults 18 to 85, any sex, with Supine Hypertension or Autonomic Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure.
Okamoto LE, Celedonio JE, Smith EC, Paranjape SY, et al · · 2023 · cited 14× · PMID 36601916 · DOI 10.1161/hypertensionaha.122.20081 -
Symptomatic Care in Multiple System Atrophy: State of the Art.
Grossauer A, Sidoroff V, Heim B, Seppi K. · · 2023 · cited 11× · PMID 35581488 · DOI 10.1007/s12311-022-01411-6
Verify or expand the search:
- PubMed search for NCT03312556
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of continuous positive airway pressure (CPAP)
Trials testing the same drug.
- NCT05376137 — Personal Therapy Comfort Settings Pilot Clinical Study · NA · completed
Other recruiting trials for Supine Hypertension
Currently open trials in the same condition.
- NCT05489575 — CPAP for the Treatment of Supine Hypertension · NA · recruiting
- NCT04502225 — Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure · NA · recruiting
Other Vanderbilt University Medical Center trials
Trials by the same sponsor.
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- NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
- NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03312556 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
- Last refreshed: 6 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03312556.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing