NCT04492631 is a NA clinical trial of Streptococcus salivarius DB-B5 in Healthy Adults, sponsored by Dose Biosystems Inc..

Who is sponsoring NCT04492631?

NCT04492631 is sponsored by Dose Biosystems Inc..

What drugs are being tested in NCT04492631?

Interventions in NCT04492631: Streptococcus salivarius DB-B5, Placebo.

What condition does NCT04492631 study?

NCT04492631 studies Healthy Adults.

Is NCT04492631 still recruiting?

NCT04492631 is currently completed. Last updated 19 October 2020.

Last reviewed 2020-10-19 · How we verify

NCT04492631

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Safety of an Oral Probiotic in Healthy Adults

Completed NA Last updated 19 October 2020

What this trial tests

NA trial testing Streptococcus salivarius DB-B5 in Healthy Adults in 64 participants. Completed in 21 September 2020.

Timeline

28 July 2020

Primary endpoint
21 September 2020

21 September 2020

Quick facts

Lead sponsor	Dose Biosystems Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	basic science
Enrollment	64
Start date	28 July 2020
Primary completion	21 September 2020
Estimated completion	21 September 2020
Sites	1 location across United States

Drugs / interventions tested

Streptococcus salivarius DB-B5
Placebo

Conditions studied

Healthy Adults — all drugs for Healthy Adults →

Sponsor

Dose Biosystems Inc.

Who can join

Adults 18 to 65, any sex, with Healthy Adults. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate the safety of an oral probiotic in healthy individuals.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Safety assessment of Streptococcus salivarius DB-B5 as a probiotic candidate for oral health.
Li X, Fields FR, Ho M, Marshall-Hudson A, et al · · 2021 · cited 16× · PMID 34004226 · DOI 10.1016/j.fct.2021.112277

Verify or expand the search:

Other recruiting trials for Healthy Adults

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NCT07284173 — A Study to Learn if a Medicine That Reduces Stomach Acid Affects the Blood Level of Study Medicine PF-08049820 in Health · Phase 1 · active not recruiting
NCT07518758 — Acute Effect of Polyphenols Supplementation on Endothelial Function and Exercise Related Markers, in Physically Active H · NA · active not recruiting

Other Dose Biosystems Inc. trials

Trials by the same sponsor.

NCT04473404 — Effect of a Probiotic Water on Oral Health in Adults · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04492631 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Dose Biosystems Inc.
Last refreshed: 19 October 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04492631.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing