Last reviewed · How we verify
NCT04483492
Direct Effect of Caffeine on Diaphragmatic Muscles
trial testing Caffeine citrate in Caffeine in 56 participants. Status unknown.
1 December 2020
Quick facts
| Lead sponsor | Hacettepe University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 56 |
| Start date | 1 March 2019 |
| Primary completion | 1 December 2020 |
| Estimated completion | 1 December 2020 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Caffeine citrate — full drug profile →
Conditions studied
- Caffeine — all drugs for Caffeine →
Sponsor
Hacettepe University
Who can join
Adults 1 Day to 7 Days, any sex, with Caffeine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The mechanism of methylxanthines is thought to increase chemoreceptor responsiveness to CO2 in central nervous system. Besides, effect of methylxanthines on diaphragmatic contractility has also been found in experimental studies. A study of premature newborns has showed caffeine increase diaphragmatic activity and tidal volume. But, there is limited data about caffeine direct effect on diaphragma. Objective: The investigators aimed to show the direct effect of caffeine on diphragmatic contractility. Method: The babies under 32 weeks with respiratory support, are being enrolled in this study if caffeine treatment is decided to receive. Evaluation of muscle contraction is being made by ultrasound before and 30 minutes after caffeine loading dose. Right and left sides of diaphragm thickness are being measured by two clinicians on B mode ultrasound by anterior subcostal view. The velocity before and after caffeine administration will be calculated, dividing excursion frequency (parameter) for inspiratory time. Movement of the diaphragm at inspiratory and expiratory phases are also observed on M mode and the difference between the two phases are measured.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Direct Effect of Caffeine on Diaphragmatic Muscles in Preterm Babies Through Ultrasonographic Examination.
Kaykı G, Çelik HT, Ayaz E, Tandırcıoğlu ÜA, et al · · 2024 · cited 1× · PMID 39140727 · DOI 10.5152/turkarchpediatr.2024.23290 -
Direct Effect of Caffeine on Diaphragmatic Muscles in Preterm Babies Through Ultrasonographic Examination
Kayki G, Celik HT, Ayaz E, Tandircioglu UA, et al · · 2022 · DOI 10.21203/rs.3.rs-1459583/v1
Verify or expand the search:
- PubMed search for NCT04483492
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Caffeine citrate
Trials testing the same drug.
- NCT06972108 — CAffeine Use in Prolonged Oxygen Use in meConium aspIration Syndrome in Neonatal Outcomes (CAPUCINO) · Phase 2 · not yet recruiting
- NCT06821698 — To Determine the Effect of KP-001 on Rosuvastatin, Caffeine PK and the Effect of Fluvoxamine on KP-001 PK in Volunteers · Phase 1 · completed
- NCT05295784 — PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia · Phase 1 · withdrawn
- NCT06097767 — the Incidence of Necrotizing Enterocolitis in Preterm With Respiratory Distress Syndrome Undergoing Caffeine Therapy · EARLY_PHASE1 · unknown
- NCT06026163 — Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress · Phase 2, PHASE3 · recruiting
Other recruiting trials for Caffeine
Currently open trials in the same condition.
- NCT07469852 — Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males · Phase 1, PHASE2 · active not recruiting
- NCT07404254 — Effects of Variations in Caffeinated Beverages on Well-being · NA · recruiting
- NCT06763172 — Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI · Phase 4 · recruiting
- NCT05325502 — Does Caffeine Facilitate Human Reward Learning Behaviors? · NA · active not recruiting
- NCT05454332 — The Caffeine Therapy in the Fetal to Neonatal Transition · Phase 4 · recruiting
Other Hacettepe University trials
Trials by the same sponsor.
- NCT07522060 — Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Us · not yet recruiting
- NCT07390162 — The Effect of Changes in the Frequency of Endotracheal Tube Repositioning in Intensive Care Units on the Prevention of O · NA · not yet recruiting
- NCT07579676 — DEVELOPMENT AND PSYCHOMETRIC EVALUATION OF THE NEUROCOGNITIVE UPPER EXTREMITY TESTS: A RELIABILITY AND VALIDITY STUDY · not yet recruiting
- NCT07524842 — Clinical Performance of Three Different Restorative Materials · NA · not yet recruiting
- NCT07439861 — The Effect of Cognitive Dual-Task on Athletic Performance Parameters in Volleyball Players With and Without Chronic Ankl · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04483492 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hacettepe University
- Last refreshed: 23 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04483492.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing