NCT04481152 (PGL-EXPO-1) is a clinical trial in Genetic Predisposition, sponsored by Assistance Publique - Hôpitaux de Paris.

Who is sponsoring NCT04481152?

NCT04481152 is sponsored by Assistance Publique - Hôpitaux de Paris.

What condition does NCT04481152 study?

NCT04481152 studies Genetic Predisposition, SDH Gene Mutation, Environmental Exposure.

Is NCT04481152 still recruiting?

NCT04481152 is currently status unknown. Last updated 19 January 2022.

Last reviewed 2022-01-19 · How we verify

NCT04481152: PGL-EXPO-1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx Paraganglioma

Status unknown Last updated 19 January 2022

What this trial tests

trial in Genetic Predisposition in 100 participants. Status unknown.

Timeline

1 March 2022

Primary endpoint
1 September 2022

1 September 2022

Quick facts

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	100
Start date	1 March 2022
Primary completion	1 September 2022
Estimated completion	1 September 2022

Conditions studied

Genetic Predisposition — all drugs for Genetic Predisposition →
SDH Gene Mutation — all drugs for SDH Gene Mutation →
Environmental Exposure — all drugs for Environmental Exposure →

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

18 and older, any sex, with Genetic Predisposition or SDH Gene Mutation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main objective of the pilot phase of PGLEXPO will be to assess the faisability and to precise methodology of a case-control study designed for testing the impact of environmental and professional exposures on the tumoral risk in SDHx-mutation carriers

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases.
Moreno C, Santos RM, Burns R, Zhang WC. · · 2020 · cited 34× · PMID 33153035 · DOI 10.3390/cancers12113237
Pheochromocytoma: a changing perspective and current concepts.
Kiriakopoulos A, Giannakis P, Menenakos E. · · 2023 · cited 12× · PMID 37916027 · DOI 10.1177/20420188231207544
PGL-EXPO feasibility study of exposure to SDHi fungicides and risk of hereditary SDHx paraganglioma or pheochromocytoma.
Coste A, Buffet A, Duboeuf M, Boudif S, et al · · 2025 · PMID 40593204 · DOI 10.1038/s41598-025-09166-w

Verify or expand the search:

Other recruiting trials for Genetic Predisposition

Currently open trials in the same condition.

NCT06089421 — Genetic Information Assistant in Telegenetics · NA · recruiting
NCT06441942 — Prospective Multicenter Registry of Gender, Diversity and Inclusion (GEDI) of Women With Acute Coronary Syndrome · recruiting
NCT06554288 — Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy · Phase 1 · recruiting
NCT06446271 — Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH) · recruiting
NCT06377033 — Using the EHR to Advance Genomic Medicine Across a Diverse Health System · NA · recruiting

Other Assistance Publique - Hôpitaux de Paris trials

Trials by the same sponsor.

NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04481152 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
Last refreshed: 19 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04481152.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing