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NCT04478591: WOC
The Wearing-off Phenomenon of Ocrelizumab in Patients With Multiple Sclerosis
trial testing Questionnaires in Multiple Sclerosis in 117 participants. Completed in 1 May 2021.
1 April 2021
Quick facts
| Lead sponsor | Amsterdam UMC, location VUmc |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 117 |
| Start date | 12 May 2020 |
| Primary completion | 1 April 2021 |
| Estimated completion | 1 May 2021 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Questionnaires
Conditions studied
- Multiple Sclerosis — all drugs for Multiple Sclerosis →
Sponsor
Amsterdam UMC, location VUmc — full company profile →
Who can join
18 and older, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary goal of this research is to study the prevalence of the wearing-off effect and possible risk factors for wearing-off symptoms in patients with multiple sclerosis using ocrelizumab with the use of questionnaires. Furthermore, the goal is to study whether patients receiving extended dosing of ocrelizumab experience more wearing-off symptoms or adverse events in general. Finally, we would like to extend knowledge on wearing-off symptoms in general.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical Perspectives on the Molecular and Pharmacological Attributes of Anti-CD20 Therapies for Multiple Sclerosis.
Bar-Or A, O'Brien SM, Sweeney ML, Fox EJ, et al · · 2021 · cited 37× · PMID 34370283 · DOI 10.1007/s40263-021-00843-8 -
A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20-Yet Progress Continues.
Frisch ES, Pretzsch R, Weber MS. · · 2021 · cited 22× · PMID 33880738 · DOI 10.1007/s13311-021-01048-z
Verify or expand the search:
- PubMed search for NCT04478591
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04478591 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Amsterdam UMC, location VUmc
- Last refreshed: 28 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04478591.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing