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NCT04475900: EyeTwin
Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
trial testing Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany) in Corneal Ectasia in 372 participants. Completed in 31 July 2022.
30 April 2022
Quick facts
| Lead sponsor | Technische Universität Dresden |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 372 |
| Start date | 9 July 2020 |
| Primary completion | 30 April 2022 |
| Estimated completion | 31 July 2022 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany)
- Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany)
- Optic nerve head measurement
Conditions studied
- Corneal Ectasia — all drugs for Corneal Ectasia →
- Corneal Disease — all drugs for Corneal Disease →
- Corneal Astigmatism — all drugs for Corneal Astigmatism →
- Keratoconus — all drugs for Keratoconus →
Sponsor
Technische Universität Dresden — full company profile →
Who can join
Adults 18 to 99, any sex, with Corneal Ectasia or Corneal Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with biomechanical alterations of the cornea. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. In glaucoma, the information about corneal alterations serves in two ways, first, correct measurement of intra ocular pressure (IOP); second, early diagnosis of suspects before visual field defects are detectable. Especially, the Corvis ST is an air-puff tonometer that measures intraocular pressure, corneal thickness (CCT) as well as dynamic corneal response (DCR) parameters. Most of the DCR parameters are affected by IOP and CCT: Therefore, algorithm are needed to determine parameters without impact of IOP and CCT that are describe the biomechanical properties of the cornea.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04475900
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other recruiting trials for Corneal Ectasia
Currently open trials in the same condition.
- NCT04698590 — Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism · NA · active not recruiting
- NCT04094090 — Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia · Phase 2 · recruiting
- NCT04251143 — Dresden Corneal Disease and Treatment Study · recruiting
Other Technische Universität Dresden trials
Trials by the same sponsor.
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- NCT03865277 — Individualized Radiation Dose Prescription in HNSCC Based on F-MISO-PET Hypoxia-Imaging · Phase 2 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04475900 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Technische Universität Dresden
- Last refreshed: 11 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04475900.
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