Who is sponsoring NCT04472481?

NCT04472481 is sponsored by Tanta University.

What drugs are being tested in NCT04472481?

Interventions in NCT04472481: Ergocalciferol 1.25 mg tablet.

What condition does NCT04472481 study?

NCT04472481 studies Active Rheumatoid Arthritis.

Is NCT04472481 still recruiting?

NCT04472481 is currently completed. Last updated 15 July 2020.

Last reviewed 2020-07-15 · How we verify

NCT04472481

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vitamin D Effect in Rheumatoid Arthritis.

Completed Phase 4 Last updated 15 July 2020

What this trial tests

Phase 4 trial testing Ergocalciferol 1.25 mg tablet in Active Rheumatoid Arthritis in 20 participants. Completed in 22 March 2020.

Timeline

6 September 2019

Primary endpoint
22 December 2019

22 March 2020

Quick facts

Lead sponsor	Tanta University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	6 September 2019
Primary completion	22 December 2019
Estimated completion	22 March 2020
Sites	1 location across Egypt

Drugs / interventions tested

Ergocalciferol 1.25 mg tablet — full drug profile →

Conditions studied

Active Rheumatoid Arthritis — all drugs for Active Rheumatoid Arthritis →

Sponsor

Tanta University

Who can join

Adults 33 to 60, any sex, with Active Rheumatoid Arthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Regulatory T (Tregs) cells play an important role in the maintenance of immunological tolerance. It decrease in the peripheral blood of rheumatoid arthritis patients. Vitamin D has an immunomodulatory and anti-inflammatory effect in rheumatoid arthritis. Vitamin D supplementation significantly enhances Tregs percentage in the peripheral blood of RA patients. So supplementation of Vit D improves rheumatoid arthritis disease activity.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Enhancing Regulatory T Cells to Treat Inflammatory and Autoimmune Diseases.
Fiyouzi T, Pelaez-Prestel HF, Reyes-Manzanas R, Lafuente EM, et al · · 2023 · cited 27× · PMID 37175505 · DOI 10.3390/ijms24097797
Vitamin D: does it help Tregs in active rheumatoid arthritis patients.
El-Banna HS, Gado SE. · · 2020 · cited 14× · PMID 32783547 · DOI 10.1080/1744666x.2020.1805317
Regulatory T lymphocytes as a treatment method for rheumatoid arthritis - Superiority of allogeneic to autologous cells.
Chmiel J, Stasiak M, Skrzypkowska M, Samson L, et al · · 2024 · cited 2× · PMID 39319132 · DOI 10.1016/j.heliyon.2024.e36512
The Role of Vitamin D in Autoimmune Diseases.
Vincenzi F, Smirne C, Tonello S, Sainaghi PP. · · 2026 · PMID 41516427 · DOI 10.3390/ijms27010555

Verify or expand the search:

Other recruiting trials for Active Rheumatoid Arthritis

Currently open trials in the same condition.

NCT06456489 — Pulse Steroid Injection in Refractory Rheumatoid Arthritis · Phase 3 · recruiting

Other Tanta University trials

Trials by the same sponsor.

NCT07398651 — Apremilast and Adalimumab in Psoriatic Arthritis Patients · NA · not yet recruiting
NCT06966856 — This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcti · Phase 3 · not yet recruiting
NCT07334197 — Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy · NA · not yet recruiting
NCT07498998 — Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome · NA · not yet recruiting
NCT07114250 — Comparative Study Between Spinal Anesthesia Versus General Anesthesia in Supine Percutaneous Nephrolithotomy Operation · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04472481 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tanta University
Last refreshed: 15 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04472481.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing