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NCT04467892
Low Versus High Corticosteroid Use in Ventilator Associated Pneumonia
Phase 2 trial testing methylprednisolone in Ventilator Associated Pneumonia in 240 participants. Completed in 25 February 2020.
14 February 2020
Quick facts
| Lead sponsor | King Abdul Aziz Specialist Hospital |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 240 |
| Start date | 2 January 2018 |
| Primary completion | 14 February 2020 |
| Estimated completion | 25 February 2020 |
| Sites | 1 location across Saudi Arabia |
Drugs / interventions tested
- methylprednisolone (methylprednisolone) — full drug profile →
- Methyl Prednisolonate — full drug profile →
- ventilators
Conditions studied
- Ventilator Associated Pneumonia — all drugs for Ventilator Associated Pneumonia →
Sponsor
King Abdul Aziz Specialist Hospital
Who can join
Adults 18 to 65, any sex, with Ventilator Associated Pneumonia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
patients who had \>3 on Murray score and \>6 on CPIS allocated randomly in two groups 120 patients in each. Group A received 30 mg/kg methyl-prednisolone slowly intravenous in 250 mL normal saline every 8 hours for only 48 hours while group B received 1 mg/kg/day methyl-prednisolone divided to three doses given every 8 hours for two weeks. Duration of the study last 16 days, Morbidity considered if no improvement in any or all clinical parameters of both Murray and CPIS scores and failure of weaning of patients from the ventilator at the studied period.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04467892
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT06623370 — The Effect of Methylprednisolone on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group · Phase 4 · completed
- NCT04826237 — Oral Statins and Protection From Hearing Loss · Phase 4 · recruiting
- NCT05137496 — Ruxolitinib and Methylprednisolone as a First-line Treatment for Macrophage Activation Syndrome · Phase 3 · unknown
Other recruiting trials for Ventilator Associated Pneumonia
Currently open trials in the same condition.
- NCT07102407 — Effect of a Constructivist Educational Program on Preventing Ventilator-Associated Pneumonia in Intensive Care Units · NA · recruiting
- NCT06554327 — Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective Regimens · NA · recruiting
- NCT05591924 — Early Severe Illness TrAnslational BioLogy InformaticS in Humans · recruiting
- NCT06092554 — Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT) · NA · recruiting
- NCT05979545 — EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics · Phase 4 · recruiting
Other King Abdul Aziz Specialist Hospital trials
Trials by the same sponsor.
- NCT05794867 — Ultrasonic Weaning Criteria in Prolonged Ventilation · completed
- NCT06072222 — Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ven · Phase 1, PHASE2 · completed
- NCT04553367 — Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ven · Phase 1, PHASE2 · completed
- NCT06072248 — Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ven · Phase 1, PHASE2 · completed
- NCT04402320 — Non Invasive and Invasive Ventilation Post Extubation · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04467892 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King Abdul Aziz Specialist Hospital
- Last refreshed: 13 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04467892.
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