NCT04449328 (OPTIVIBE) is a NA clinical trial of Computerized Mirror Therapy (CMT) in Hemiplegia, sponsored by Centre Hospitalier Universitaire de Saint Etienne.

Who is sponsoring NCT04449328?

NCT04449328 is sponsored by Centre Hospitalier Universitaire de Saint Etienne.

What drugs are being tested in NCT04449328?

Interventions in NCT04449328: Computerized Mirror Therapy (CMT), Tendon vibration.

What condition does NCT04449328 study?

NCT04449328 studies Hemiplegia.

Is NCT04449328 still recruiting?

NCT04449328 is currently terminated. Last updated 30 May 2023.

Last reviewed 2023-05-30 · How we verify

NCT04449328: OPTIVIBE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Induced Motion Illusions Through Vision and Tendon Vibrations: Study of Interactions in Hemiplegic Subjects

Terminated NA Last updated 30 May 2023

What this trial tests

NA trial testing Computerized Mirror Therapy (CMT) in Hemiplegia in 33 participants. Terminated before completion.

Timeline

30 April 2021

Primary endpoint
25 April 2023

28 April 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Saint Etienne
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	33
Start date	30 April 2021
Primary completion	25 April 2023
Estimated completion	28 April 2023
Sites	1 location across France

Drugs / interventions tested

Computerized Mirror Therapy (CMT)
Tendon vibration

Conditions studied

Hemiplegia — all drugs for Hemiplegia →

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Who can join

Adults 18 to 70, any sex, with Hemiplegia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Two movement illusion techniques can currently be used in clinical practice for motor rehabilitation after stroke hemiplegia: visual illusion (mirror therapy) and proprioceptive illusion (tendon vibration). Mirror therapy, in its computerized version (IVS3, Dessintey, Saint-Etienne, France), is based on the substitution of the deficient visual feedback by a visual feedback of a correctly realized movement. The proprioceptive illusion is based on the external application of a vibrator on muscle tendons at a frequency between 50 and 120 Hz. These two techniques are currently used independently. They are, in theory, complementary and additive. No study has described the combinatorial properties of the illusions generated by these 2 techniques in hemiplegic subjects and healthy subjects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Distinct and additive effects of visual and vibratory feedback for motor rehabilitation: an EEG study in healthy subjects.
Adham A, Bessaguet H, Struber L, Rimaud D, et al · · 2024 · cited 1× · PMID 39267092 · DOI 10.1186/s12984-024-01453-3

Verify or expand the search:

Other trials of Computerized Mirror Therapy (CMT)

Trials testing the same drug.

NCT03815266 — Feasibility Study to Evaluate the Observance Rehabilitation of Upper Limbs by Visual-motor Simulation Associated at Tran · NA · terminated

Other recruiting trials for Hemiplegia

Currently open trials in the same condition.

NCT07386119 — Investigation of the Effects of Vestibular Rehabilitation and Dynamic Neuromuscular · NA · active not recruiting
NCT07304180 — Exergame vs Balance Training in Hemiplegia · NA · active not recruiting
NCT07261007 — Investigation of the Effectiveness of Flossing in Hemiplegic Patients With Shoulder Pain · NA · recruiting
NCT07063446 — sTMS Combined With CIMT and taVNS In Infants With Hemiplegia · NA · recruiting
NCT07240337 — Botulinum Toxin Applications in Hemiplegic Patients · recruiting

Other Centre Hospitalier Universitaire de Saint Etienne trials

Trials by the same sponsor.

NCT07326579 — Effects of a Sleep Education Program on the Health Status of Healthcare Workers Working 12-hour Alternating Day-night Sh · NA · not yet recruiting
NCT07504003 — Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise · NA · recruiting
NCT07483710 — Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission an · NA · not yet recruiting
NCT06845176 — Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery · NA · recruiting
NCT07344298 — Less is Better? Effectiveness of a Short Local Vibration Protocol on Neuromuscular Function · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04449328 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire de Saint Etienne
Last refreshed: 30 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04449328.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing