NCT04424576 (OMG) is a clinical trial in Amenorrhea, sponsored by Cornell University.

Who is sponsoring NCT04424576?

NCT04424576 is sponsored by Cornell University.

What condition does NCT04424576 study?

NCT04424576 studies Amenorrhea, Oligomenorrhea, Puberty.

Is NCT04424576 still recruiting?

NCT04424576 is currently recruiting now. Last updated 12 August 2024.

Last reviewed 2024-08-12 · How we verify

NCT04424576: OMG

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ovarian Morphology in Girls

Recruiting now Last updated 12 August 2024

What this trial tests

trial in Amenorrhea in 60 participants. Currently enrolling.

Timeline

31 January 2020

Primary endpoint
31 March 2025

31 March 2025

Quick facts

Lead sponsor	Cornell University
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	60
Start date	31 January 2020
Primary completion	31 March 2025
Estimated completion	31 March 2025
Sites	3 locations across United States

Conditions studied

Amenorrhea — all drugs for Amenorrhea →
Oligomenorrhea — all drugs for Oligomenorrhea →
Puberty — all drugs for Puberty →

Sponsor

Cornell University

Who can join

Adults 9 to 17, female only, with Amenorrhea or Oligomenorrhea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predictor of normal or abnormal development by following the trajectory of ovarian morphology in conjunction with menstrual cyclicity using 3D transabdominal ultrasound imaging in a prospective cohort study of adolescents. A secondary objective is to identify potential environmental factors such as diet and the gut microbiome which influence the trajectory towards normal or abnormal reproductive development.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
Vanden Brink H, Vandeputte D, Brito IL, Ronnekleiv OK, et al · · 2024 · cited 11× · PMID 39082696 · DOI 10.1210/endocr/bqae098

Verify or expand the search:

Other recruiting trials for Amenorrhea

Currently open trials in the same condition.

NCT06280807 — Observation of Environment and Reproductive-Endocrine Effects · recruiting
NCT03916978 — Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women · Phase 2, PHASE3 · recruiting
NCT01500447 — Inherited Reproductive Disorders · recruiting

Other Cornell University trials

Trials by the same sponsor.

NCT07439198 — The Influence of Water Intake on Food Intake at Meals Varying in Moisture · NA · not yet recruiting
NCT07224412 — A Digital Intervention to Promote Preschool Nutrition and Activity: The eHEROs Study · NA · recruiting
NCT06880510 — The Locus Coeruleus, Norepinephrine and Cognitive Aging · NA · recruiting
NCT06870526 — Feasibility of Online-supported Delivery Bringing Optimal Nutrition to Diverse Low-income Households With Children · NA · completed
NCT06988410 — Income Volatility and Mental Health, Full Experiment · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04424576 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cornell University
Last refreshed: 12 August 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04424576.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing